Now 30 years old, the chronic mild stress (CMS) model of depression has been used in>
1300 published studies, with a year-on-year increase rising to> 200 papers in 2015. Data …

Extensive research within the last several decades has revealed that the major risk factors
for most chronic diseases are infections, obesity, alcohol, tobacco, radiation, environmental …

Alzheimer's disease (AD) is a severe, chronic and progressive neurodegenerative disease
associated with memory and cognition impairment ultimately leading to death. It is the …

Background Depressed patients present increased plasma levels of lipopolysaccharide
(LPS) and neuroinflammatory alterations. Here, we determined the neuroimmune effects of …

Piperine, an alkaloid from black pepper, has demonstrated beneficial effects in central
nervous system, especially in epilepsy control. However, its therapeutic application remains …

Our working hypothesis is that brain neurotrophins and brain Na+, K+-ATPase may be
strongly associated with the occurrence of depression in animals subjected to chronic …

L-tryptophan (Trp) contributes to regulating bilateral communication of the gut–brain axis. It
undergoes three major metabolic pathways, which lead to formation of kynurenine …

Gastric cancer (GC) is the fifth most cancer type and the third most cause of cancer-
associated deaths worldwide along with the 5-year survival rate is less the 30%. This …

Piperine (PIP) is a natural alkaloid isolated from Piper longum L. that presents antioxidant,
anticonvulsant, antimicrobial, neuroprotective, larvicidal, antiparasitic, anticancer effect and …

Early-life challenges, particularly infections and stress, are related to neuropsychiatric
disorders such as autism and schizophrenia. Here, we conducted a wide range of …