Influenza A viruses (IAVs) are contagious pathogens responsible for severe respiratory
infection in humans and animals worldwide. Upon detection of IAV infection, host immune …

Seasonal influenza viruses cause recurring global epidemics by continually evolving to
escape host immunity. The viral constraints and host immune responses that limit and drive …

The transmission of dengue virus (DENV) from an infected Aedes mosquito to a human,
causes illness ranging from mild dengue fever to fatal dengue shock syndrome. The similar …

Highly effective vaccines elicit specific, robust, and durable adaptive immune responses. To
advance informed vaccine design, it is critical that we understand the cellular dynamics …

During the last few decades, the global incidence of dengue virus (DENV) has increased
dramatically, and it is now endemic in more than 100 countries. To establish a productive …

Dengue virus (DENV) is a pathogen with a high impact on human health. It replicates in a
wide range of cells involved in the immune response. To efficiently infect humans, DENV …

Influenza A viruses are zoonotic pathogens that continuously circulate and change in
several animal hosts, including birds, pigs, horses and humans. The emergence of novel …

In global terms, respiratory viral infection is a major cause of morbidity and mortality. Infancy,
in particular, is a time of increased disease susceptibility and severity. Early-life viral …

Double-stranded RNA (dsRNA) produced during viral replication is believed to be the critical
trigger for activation of antiviral immunity mediated by the RNA helicase enzymes retinoic …

The interferon (IFN) system is an extremely powerful antiviral response that is capable of
controlling most, if not all, virus infections in the absence of adaptive immunity. However …