[HTML][HTML] Emerging technologies in algal biotechnology: toward the establishment of a sustainable, algae-based bioeconomy
Mankind has recognized the value of land plants as renewable sources of food, medicine,
and materials for millennia. Throughout human history, agricultural methods were …
and materials for millennia. Throughout human history, agricultural methods were …
[HTML][HTML] Discovery and resupply of pharmacologically active plant-derived natural products: A review
AG Atanasov, B Waltenberger… - Biotechnology …, 2015 - Elsevier
Medicinal plants have historically proven their value as a source of molecules with
therapeutic potential, and nowadays still represent an important pool for the identification of …
therapeutic potential, and nowadays still represent an important pool for the identification of …
[HTML][HTML] Single-cell multi-omics in the medicinal plant Catharanthus roseus
Advances in omics technologies now permit the generation of highly contiguous genome
assemblies, detection of transcripts and metabolites at the level of single cells and high …
assemblies, detection of transcripts and metabolites at the level of single cells and high …
Single-cell RNA sequencing provides a high-resolution roadmap for understanding the multicellular compartmentation of specialized metabolism
S Sun, X Shen, Y Li, Y Li, S Wang, R Li, H Zhang… - Nature plants, 2023 - nature.com
Monoterpenoid indole alkaloids (MIAs) are among the most diverse specialized metabolites
in plants and are of great pharmaceutical importance. We leveraged single-cell …
in plants and are of great pharmaceutical importance. We leveraged single-cell …
Discovery and engineering of colchicine alkaloid biosynthesis
RS Nett, W Lau, ES Sattely - Nature, 2020 - nature.com
Few complete pathways have been established for the biosynthesis of medicinal
compounds from plants. Accordingly, many plant-derived therapeutics are isolated directly …
compounds from plants. Accordingly, many plant-derived therapeutics are isolated directly …
Transforming yeast peroxisomes into microfactories for the efficient production of high-value isoprenoids
S Dusséaux, WT Wajn, Y Liu, C Ignea… - Proceedings of the …, 2020 - National Acad Sciences
Current approaches for the production of high-value compounds in microorganisms mostly
use the cytosol as a general reaction vessel. However, competing pathways and metabolic …
use the cytosol as a general reaction vessel. However, competing pathways and metabolic …
[HTML][HTML] The scaffold-forming steps of plant alkaloid biosynthesis
BR Lichman - Natural Product Reports, 2021 - pubs.rsc.org
Alkaloids from plants are characterised by structural diversity and bioactivity, and maintain a
privileged position in both modern and traditional medicines. In recent years, there have …
privileged position in both modern and traditional medicines. In recent years, there have …
[HTML][HTML] A chromosome-level Camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis
M Kang, R Fu, P Zhang, S Lou, X Yang, Y Chen… - Nature …, 2021 - nature.com
Camptothecin and its derivatives are widely used for treating malignant tumors. Previous
studies revealed only a limited number of candidate genes for camptothecin biosynthesis in …
studies revealed only a limited number of candidate genes for camptothecin biosynthesis in …
De novo production of the plant-derived alkaloid strictosidine in yeast
S Brown, M Clastre, V Courdavault… - Proceedings of the …, 2015 - National Acad Sciences
The monoterpene indole alkaloids are a large group of plant-derived specialized
metabolites, many of which have valuable pharmaceutical or biological activity. There are∼ …
metabolites, many of which have valuable pharmaceutical or biological activity. There are∼ …
Jasmonate-responsive transcription factors regulating plant secondary metabolism
M Zhou, J Memelink - Biotechnology advances, 2016 - Elsevier
Plants produce a large variety of secondary metabolites including alkaloids, glucosinolates,
terpenoids and phenylpropanoids. These compounds play key roles in plant–environment …
terpenoids and phenylpropanoids. These compounds play key roles in plant–environment …