Human breast tissue engineering in health and disease

MB Buchholz, DI Scheerman, R Levato… - EMBO Molecular …, 2024 - embopress.org
The human mammary gland represents a highly organized and dynamic tissue, uniquely
characterized by postnatal developmental cycles. During pregnancy and lactation, it …

Recording morphogen signals reveals mechanisms underlying gastruloid symmetry breaking

HM McNamara, SC Solley, B Adamson, MM Chan… - Nature cell …, 2024 - nature.com
Aggregates of stem cells can break symmetry and self-organize into embryo-like structures
with complex morphologies and gene expression patterns. Mechanisms including reaction …

Four-Dimensional Bioprinting: Harnessing Active Mechanics to Build with Living Inks

H Kim, G Hu, AJ Graham, GX Gu… - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
Abstract Three-dimensional (3D) printing can be beneficial to tissue engineers and the
regenerative medicine community because of its potential to rapidly build elaborate 3D …

MAGIC matrices: freeform bioprinting materials to support complex and reproducible organoid morphogenesis

AJ Graham, MWL Khoo, V Srivastava, S Viragova… - …, 2024 - pmc.ncbi.nlm.nih.gov
Organoids are powerful models of tissue physiology, yet their applications remain limited
due to their relatively simple morphology and high organoid-to-organoid structural …

Making sense of chaos: uncovering the mechanisms of conformational entropy

S Wankowicz, J Fraser - 2023 - chemrxiv.org
By converting a disordered polymer into a globular structure, protein folding reduces many
conformational degrees of freedom, resulting in a significant conformational entropy penalty …