NF‐κB signaling in inflammation and cancer

T Zhang, C Ma, Z Zhang, H Zhang, H Hu - MedComm, 2021 - Wiley Online Library
Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered
in 1986, extraordinary efforts have been made to understand the function and regulating …

NF‐κB and the link between inflammation and cancer

JA DiDonato, F Mercurio, M Karin - Immunological reviews, 2012 - Wiley Online Library
The nuclear factor‐κB (NF‐κB) transcription factor family has been considered the central
mediator of the inflammatory process and a key participant in innate and adaptive immune …

MYC/BCL2 protein coexpression contributes to the inferior survival of activated B-cell subtype of diffuse large B-cell lymphoma and demonstrates high-risk gene …

S Hu, ZY Xu-Monette, A Tzankov… - Blood, The Journal …, 2013 - ashpublications.org
Diffuse large B-cell lymphoma (DLBCL) is stratified into prognostically favorable germinal
center B-cell (GCB)–like and unfavorable activated B-cell (ABC)–like subtypes based on …

Diffuse large B-cell lymphoma—treatment approaches in the molecular era

M Roschewski, LM Staudt, WH Wilson - Nature reviews Clinical …, 2014 - nature.com
Diffuse large B-cell lymphoma (DLBCL) is an aggressive B-cell non-Hodgkin lymphoma that
affects patients of all ages with a wide range of clinical presentations. Although DLBCL is …

NF-κB subunits direct kinetically distinct transcriptional cascades in antigen receptor-activated B cells

M Zhao, P Chauhan, CA Sherman, A Singh… - Nature …, 2023 - nature.com
The nuclear factor kappa B (NF-κB) family of transcription factors orchestrates signal-
induced gene expression in diverse cell types. Cellular responses to NF-κB activation are …

Siglec-15/sialic acid axis as a central glyco-immune checkpoint in breast cancer bone metastasis

Y Wang, Z Xu, KL Wu, L Yu, C Wang… - Proceedings of the …, 2024 - National Acad Sciences
Immunotherapy is a promising approach for treating metastatic breast cancer (MBC), offering
new possibilities for therapy. While checkpoint inhibitors have shown great progress in the …

The NF-κB pathway and cancer stem cells

AL Rinkenbaugh, AS Baldwin - Cells, 2016 - mdpi.com
The NF-κB transcription factor pathway is a crucial regulator of inflammation and immune
responses. Additionally, aberrant NF-κB signaling has been identified in many types of …

Regulation of NF‐κB by ubiquitination and degradation of the IκBs

N Kanarek, Y Ben‐Neriah - Immunological reviews, 2012 - Wiley Online Library
The nuclear factor‐κB (NF‐κB) signaling pathway is a busy ground for the action of the
ubiquitin–proteasome system; many of the signaling steps are coordinated by protein …

The role of the transcription factor nuclear factor-kappa B in thyroid autoimmunity and cancer

C Giuliani, I Bucci, G Napolitano - Frontiers in endocrinology, 2018 - frontiersin.org
Nuclear factor-kappa B (NF-κB) is a ubiquitous transcription factor that is involved in
inflammatory and immune responses, as well as in regulation of expression of many other …

Regulation of cell death and autophagy by IKK and NF‐κB: critical mechanisms in immune function and cancer

AS Baldwin - Immunological reviews, 2012 - Wiley Online Library
The cellular response to survive or to undergo death is fundamental to the benefit of the
organism, and errors in this process can lead to autoimmunity and cancer. The transcription …