Sphingolipids are essential components of all eukaryotic membranes. The bioactive
sphingolipid molecule, Sphingosine 1-Phosphate (S1P), regulates various important …

Redox medicine is a new therapeutic concept targeting reactive oxygen species (ROS) and
secondary reaction products for health benefit. The concomitant function of ROS as …

Sphingosine-1-phosphate (S1P) is a bioactive lipid molecule that is present in all eukaryotic
cells and plays key roles in various extracellular, cytosolic, and nuclear signaling pathways …

Background Sepsis is an abnormal immune response after infection, wherein the lung is the
most susceptible organ to fail, leading to acute lung injury. To overcome the limitations of …

The Covid-19 pandemic driven by the SARS-CoV-2 virus continues to exert extensive
humanitarian and economic stress across the world. Although antivirals active against mild …

Management of acute respiratory distress involves O2 supplementation, which is lifesaving,
but causes severe hyperoxic acute lung injury (HALI). NADPH oxidase (NOX) could be a …

Abstract Sphingosine-1-phosphate (S1P), a bioactive lipid mediator, is generated from
sphingosine by sphingosine kinases (SPHKs) 1 and 2 and is metabolized to∆ 2 …

When the lungs are infected with bacteria, alveolar macrophages (AMs) are recruited to the
site and play a crucial role in protecting the host by reducing excessive lung inflammation …

Acute inflammation in the lung is essential for host defense against pathogens and other
injuries but chronic or excessive inflammation can contribute to several common respiratory …

Sphingolipids have been studied under several pathological conditions, and their impacts
on a variety of cellular and biological functions have been demonstrated in different types of …