[HTML][HTML] Inflammation context in Alzheimer's disease, a relationship intricate to define
C Novoa, P Salazar, P Cisternas, C Gherardelli… - Biological Research, 2022 - Springer
Abstract Alzheimer's disease (AD), the most common form of dementia, is characterized by
the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates …
the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates …
Mouse models of Alzheimer's disease
G Esquerda-Canals, L Montoliu-Gaya… - Journal of …, 2017 - content.iospress.com
Alzheimer's disease (AD) is a neurodegenerative disorder that nowadays affects more than
40 million people worldwide and it is predicted to exponentially increase in the coming …
40 million people worldwide and it is predicted to exponentially increase in the coming …
Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes
M Pajares, N Jiménez-Moreno, ÁJ García-Yagüe… - Autophagy, 2016 - Taylor & Francis
Autophagy is a highly coordinated process that is controlled at several levels including
transcriptional regulation. Here, we identify the transcription factor NFE2L2/NRF2 (nuclear …
transcriptional regulation. Here, we identify the transcription factor NFE2L2/NRF2 (nuclear …
[HTML][HTML] Tau aggregation and its interplay with amyloid-β
Neurofibrillary tangles and amyloid plaques constitute the hallmark brain lesions of
Alzheimer's disease (AD) patients. Tangles are composed of fibrillar aggregates of the …
Alzheimer's disease (AD) patients. Tangles are composed of fibrillar aggregates of the …
[HTML][HTML] Ocular indicators of Alzheimer's: exploring disease in the retina
Although historically perceived as a disorder confined to the brain, our understanding of
Alzheimer's disease (AD) has expanded to include extra-cerebral manifestation, with …
Alzheimer's disease (AD) has expanded to include extra-cerebral manifestation, with …
[HTML][HTML] Animal models of Alzheimer's disease: Applications, evaluation, and perspectives
ZY Chen, Y Zhang - Zoological Research, 2022 - ncbi.nlm.nih.gov
Although great advances in elucidating the molecular basis and pathogenesis of
Alzheimer's disease (AD) have been made and multifarious novel therapeutic approaches …
Alzheimer's disease (AD) have been made and multifarious novel therapeutic approaches …
[HTML][HTML] Alzheimer's retinopathy: seeing disease in the eyes
The neurosensory retina emerges as a prominent site of Alzheimer's disease (AD)
pathology. As a CNS extension of the brain, the neuro retina is easily accessible for …
pathology. As a CNS extension of the brain, the neuro retina is easily accessible for …
[HTML][HTML] Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation
MP Kummer, M Hermes, A Delekarte… - Neuron, 2011 - cell.com
Part of the inflammatory response in Alzheimer's disease (AD) is the upregulation of the
inducible nitric oxide synthase (NOS2) resulting in increased NO production. NO contributes …
inducible nitric oxide synthase (NOS2) resulting in increased NO production. NO contributes …
[HTML][HTML] Retinal vasculopathy in Alzheimer's disease
The retina has been increasingly investigated as a site of Alzheimer's disease (AD)
manifestation for over a decade. Early reports documented degeneration of retinal ganglion …
manifestation for over a decade. Early reports documented degeneration of retinal ganglion …
Actin dynamics and cofilin‐actin rods in Alzheimer disease
JR Bamburg, BW Bernstein - Cytoskeleton, 2016 - Wiley Online Library
Cytoskeletal abnormalities and synaptic loss, typical of both familial and sporadic Alzheimer
disease (AD), are induced by diverse stresses such as neuroinflammation, oxidative stress …
disease (AD), are induced by diverse stresses such as neuroinflammation, oxidative stress …