Decision support systems for personalized and participative radiation oncology
A paradigm shift from current population based medicine to personalized and participative
medicine is underway. This transition is being supported by the development of clinical …
medicine is underway. This transition is being supported by the development of clinical …
Modern clinical research: How rapid learning health care and cohort multiple randomised clinical trials complement traditional evidence based medicine
Background. Trials are vital in informing routine clinical care; however, current designs have
major deficiencies. An overview of the various challenges that face modern clinical research …
major deficiencies. An overview of the various challenges that face modern clinical research …
Relating the proton relative biological effectiveness to tumor control and normal tissue complication probabilities assuming interpatient variability in α/β
H Paganetti - Acta Oncologica, 2017 - Taylor & Francis
Background: Proton therapy uses a constant relative biological effectiveness (RBE) of 1.1.
The use of variable RBE values has been suggested but is currently not feasible due to …
The use of variable RBE values has been suggested but is currently not feasible due to …
Patient-specific tumor growth trajectories determine persistent and resistant cancer cell populations during treatment with targeted therapies
The importance of preexisting versus acquired drug resistance in patients with cancer
treated with small-molecule tyrosine kinase inhibitors (TKI) remains controversial. The goal …
treated with small-molecule tyrosine kinase inhibitors (TKI) remains controversial. The goal …
Library of deep-learning image segmentation and outcomes model-implementations
An open-source library of implementations for deep-learning-based image segmentation
and outcomes models based on radiotherapy and radiomics is presented. As oncology …
and outcomes models based on radiotherapy and radiomics is presented. As oncology …
Patient‐specific voxel‐level dose prescription for prostate cancer radiotherapy considering tumor cell density and grade distribution
Background In prostate radiation therapy, recent studies have indicated a benefit in
increasing the dose to intraprostatic lesions (IPL) compared with standard whole gland …
increasing the dose to intraprostatic lesions (IPL) compared with standard whole gland …
A tumour control probability model for radiotherapy of prostate cancer using magnetic resonance imaging-based apparent diffusion coefficient maps
O Casares-Magaz, UA Van der Heide, J Rørvik… - Radiotherapy and …, 2016 - Elsevier
Background and purpose Standard tumour control probability (TCP) models assume uniform
tumour cell density across the tumour. The aim of this study was to develop an individualised …
tumour cell density across the tumour. The aim of this study was to develop an individualised …
A validated tumor control probability model based on a meta‐analysis of low, intermediate, and high‐risk prostate cancer patients treated by photon, proton, or carbon …
Purpose: A fully heterogeneous population averaged mechanistic tumor control probability
(TCP) model is appropriate for the analysis of external beam radiotherapy (EBRT). This has …
(TCP) model is appropriate for the analysis of external beam radiotherapy (EBRT). This has …
Predicting the 5-year risk of biochemical relapse after postprostatectomy radiation therapy in≥ PT2, pN0 patients with a comprehensive tumor control probability …
C Fiorino, S Broggi, N Fossati, C Cozzarini… - International Journal of …, 2016 - Elsevier
Purpose To fit the individual biochemical recurrence-free survival (bRFS) data from patients
treated with postprostatectomy radiation therapy (RT) with a comprehensive tumor control …
treated with postprostatectomy radiation therapy (RT) with a comprehensive tumor control …
Accurate prediction of long-term risk of biochemical failure after salvage radiotherapy including the impact of pelvic node irradiation
C Cozzarini, M Olivieri, A Magli, D Cante… - Radiotherapy and …, 2022 - Elsevier
Background and purpose Explainable models of long-term risk of biochemical failure (BF)
after post-prostatectomy salvage radiotherapy (SRT) are lacking. A previously introduced …
after post-prostatectomy salvage radiotherapy (SRT) are lacking. A previously introduced …