Neuronal networks are capable of undergoing rapid structural and functional changes called
plasticity, which are essential for shaping circuit function during nervous system …

Hubel and Wiesel began the modern study of development and plasticity of primary visual
cortex (V1), discovering response properties of cortical neurons that distinguished them from …

LTP and LTD, the long-term potentiation and depression of excitatory synaptic transmission,
are widespread phenomena expressed at possibly every excitatory synapse in the …

Proper establishment of synapses is critical for constructing functional circuits. Interactions
between presynaptic neurexins and postsynaptic neuroligins coordinate the formation of …

Thirty years have passed since the publication of Elie Bienenstock, Leon Cooper and Paul
Munro's' Theory for the development of neuron selectivity: orientation specificity and …

Sensory experience and learning alter sensory representations in cerebral cortex. The
synaptic mechanisms underlying sensory cortical plasticity have long been sought. Recent …

Recent studies have made progress in characterizing the determinants of critical periods for
experience-dependent plasticity. They highlight the role of neurotrophins, NMDA receptors …

Synapses are complex because they perform multiple functions, including at least six
mechanistically different forms of plasticity. Here, I comment on recent developments …

Sensory experience is crucial in the refinement of synaptic connections in the brain during
development. It has been suggested that some forms of experience-dependent synaptic …

In the visual cortex, as elsewhere, N-methyl-d-aspartate receptors (NMDARs) play a critical
role in triggering long-term, experience-dependent synaptic plasticity. Modifications of …