The multifaceted role of neurofilament light chain protein in non-primary neurological diseases
The advancing validation and exploitation of CSF and blood neurofilament light chain
protein as a biomarker of neuroaxonal damage has deeply changed the current diagnostic …
protein as a biomarker of neuroaxonal damage has deeply changed the current diagnostic …
[HTML][HTML] Neuropsychiatric manifestations of COVID-19, potential neurotropic mechanisms, and therapeutic interventions
Y Han, K Yuan, Z Wang, WJ Liu, ZA Lu, L Liu… - Translational …, 2021 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has caused large-scale
economic and social losses and worldwide deaths. Although most COVID-19 patients have …
economic and social losses and worldwide deaths. Although most COVID-19 patients have …
One-year trajectory of cognitive changes in older survivors of COVID-19 in Wuhan, China: a longitudinal cohort study
YH Liu, Y Chen, QH Wang, LR Wang, L Jiang… - JAMA …, 2022 - jamanetwork.com
Importance Determining the long-term impact of COVID-19 on cognition is important to
inform immediate steps in COVID-19 research and health policy. Objective To investigate …
inform immediate steps in COVID-19 research and health policy. Objective To investigate …
[HTML][HTML] SARS-CoV-2 Spike protein induces TLR4-mediated long-term cognitive dysfunction recapitulating post-COVID-19 syndrome in mice
FL Fontes-Dantas, GG Fernandes, EG Gutman… - Cell reports, 2023 - cell.com
Cognitive dysfunction is often reported in patients with post-coronavirus disease 2019
(COVID-19) syndrome, but its underlying mechanisms are not completely understood …
(COVID-19) syndrome, but its underlying mechanisms are not completely understood …
Comparison of serum neurodegenerative biomarkers among hospitalized COVID‐19 patients versus non‐COVID subjects with normal cognition, mild cognitive …
JA Frontera, A Boutajangout, AV Masurkar… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction Neurological complications among hospitalized COVID‐19 patients may be
associated with elevated neurodegenerative biomarkers. Methods Among hospitalized …
associated with elevated neurodegenerative biomarkers. Methods Among hospitalized …
Brain injury in COVID-19 is associated with dysregulated innate and adaptive immune responses
COVID-19 is associated with neurological complications including stroke, delirium and
encephalitis. Furthermore, a post-viral syndrome dominated by neuropsychiatric symptoms …
encephalitis. Furthermore, a post-viral syndrome dominated by neuropsychiatric symptoms …
Dendrimer nanotherapy for severe COVID-19 attenuates inflammation and neurological injury markers and improves outcomes in a phase2a clinical trial
AM Gusdon, N Faraday, JS Aita, S Kumar… - Science translational …, 2022 - science.org
Hyperinflammation triggered by SARS-CoV-2 is a major cause of disease severity, with
activated macrophages implicated in this response. OP-101, a hydroxyl-polyamidoamine …
activated macrophages implicated in this response. OP-101, a hydroxyl-polyamidoamine …
[HTML][HTML] Hippocampal subfield abnormalities and biomarkers of pathologic brain changes: from SARS-CoV-2 acute infection to post-COVID syndrome
M Díez-Cirarda, M Yus-Fuertes, R Sanchez-Sanchez… - …, 2023 - thelancet.com
Background Cognitive deficits are among the main disabling symptoms in COVID-19
patients and post-COVID syndrome (PCS). Within brain regions, the hippocampus, a key …
patients and post-COVID syndrome (PCS). Within brain regions, the hippocampus, a key …
Widespread white matter oedema in subacute COVID-19 patients with neurological symptoms
While neuropathological examinations in patients who died from COVID-19 revealed
inflammatory changes in cerebral white matter, cerebral MRI frequently fails to detect …
inflammatory changes in cerebral white matter, cerebral MRI frequently fails to detect …
[HTML][HTML] Fluid biomarkers for amyotrophic lateral sclerosis: a review
KE Irwin, U Sheth, PC Wong, TF Gendron - Molecular neurodegeneration, 2024 - Springer
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the loss of upper and lower motor neurons. Presently, three FDA-approved drugs are …
the loss of upper and lower motor neurons. Presently, three FDA-approved drugs are …