Applications of amyloid, tau, and neuroinflammation PET imaging to Alzheimer's disease and mild cognitive impairment

A Chandra, PE Valkimadi, G Pagano… - Human brain …, 2019 - Wiley Online Library
Alzheimer's disease (AD) is a devastating and progressive neurodegenerative disease for
which there is no cure. Mild cognitive impairment (MCI) is considered a prodromal stage of …

Recent update on the heterogeneity of the Alzheimer's disease spectrum

KA Jellinger - Journal of Neural Transmission, 2022 - Springer
Abstract Alzheimer's disease (AD), the most common form of dementia worldwide, is a mixed
proteinopathy (β-amyloid, tau and other proteins). Classically defined as a …

Distinct tau PET patterns in atrophy‐defined subtypes of Alzheimer's disease

R Ossenkoppele, CH Lyoo, CH Sudre… - Alzheimer's & …, 2020 - Wiley Online Library
Introduction Differential patterns of brain atrophy on structural magnetic resonance imaging
(MRI) revealed four reproducible subtypes of Alzheimer's disease (AD):(1)“typical”,(2)“limbic …

Characterization of the logopenic variant of primary progressive aphasia: a systematic review and meta-analysis

F Conca, V Esposito, G Giusto, SF Cappa… - Ageing Research …, 2022 - Elsevier
The linguistic and anatomical variability of the logopenic variant of Primary Progressive
Aphasia (lv-PPA) as defined by current diagnostic criteria has been the topic of an intense …

Pathobiological subtypes of Alzheimer disease

KA Jellinger - Dementia and Geriatric Cognitive Disorders, 2021 - karger.com
Alzheimer disease (AD), the most common form of dementia, is a heterogenous disorder
with various pathobiological subtypes. In addition to the 4 major subtypes based on the …

Tau and amyloid relationships with resting-state functional connectivity in atypical Alzheimer's disease

I Sintini, J Graff-Radford, DT Jones, H Botha… - Cerebral …, 2021 - academic.oup.com
The mechanisms through which tau and amyloid-beta (Aβ) accumulate in the brain of
Alzheimer's disease patients may differ but both are related to neuronal networks. We …

Longitudinal neuroimaging biomarkers differ across Alzheimer's disease phenotypes

I Sintini, J Graff-Radford, ML Senjem, CG Schwarz… - Brain, 2020 - academic.oup.com
Alzheimer's disease can present clinically with either the typical amnestic phenotype or with
atypical phenotypes, such as logopenic progressive aphasia and posterior cortical atrophy …

[HTML][HTML] Tau covariance patterns in Alzheimer's disease patients match intrinsic connectivity networks in the healthy brain

R Ossenkoppele, L Iaccarino, DR Schonhaut… - NeuroImage: Clinical, 2019 - Elsevier
According to the network model of neurodegeneration, the spread of pathogenic proteins
occurs selectively along connected brain regions. We tested in vivo whether the distribution …

Neuropathological assessment of the Alzheimer spectrum

KA Jellinger - Journal of Neural Transmission, 2020 - Springer
Alzheimer disease (AD), the most common form of dementia globally, classically defined a
clinicopathological entity, is a heterogenous disorder with various pathobiological subtypes …

Regional multimodal relationships between tau, hypometabolism, atrophy, and fractional anisotropy in atypical Alzheimer's disease

I Sintini, CG Schwarz, PR Martin… - Human brain …, 2019 - Wiley Online Library
Alzheimer's disease (AD) can present with atypical clinical forms where the prominent
domain of deficit is not memory, that is, atypical AD. Atypical AD patients show cortical …