Zebrafish as an animal model for biomedical research
Zebrafish have several advantages compared to other vertebrate models used in modeling
human diseases, particularly for large-scale genetic mutant and therapeutic compound …
human diseases, particularly for large-scale genetic mutant and therapeutic compound …
Advances in zebrafish as a comprehensive model of mental disorders
L Wang, F Liu, Y Fang, J Ma, J Wang, L Qu… - Depression and …, 2023 - Wiley Online Library
As an important part in international disease, mental disorders seriously damage human
health and social stability, which show the complex pathogenesis and increasing incidence …
health and social stability, which show the complex pathogenesis and increasing incidence …
[HTML][HTML] Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism
AJ Khalaj, FH Sterky, A Sclip, J Schwenk… - Journal of Cell …, 2020 - rupress.org
Neurexins are presynaptic adhesion molecules that organize synapses by binding to
diverse trans-synaptic ligands, but how neurexins are regulated is incompletely understood …
diverse trans-synaptic ligands, but how neurexins are regulated is incompletely understood …
Stress-induced changes in social dominance are scaled by AMPA-type glutamate receptor phosphorylation in the medial prefrontal cortex
The establishment and maintenance of social dominance are critical for social stability and
the survival and health of individual animals. Stress lead to depression and a decrease in …
the survival and health of individual animals. Stress lead to depression and a decrease in …
FAM19A (TAFA): An emerging family of neurokines with diverse functions in the central and peripheral nervous system
DC Sarver, X Lei, GW Wong - ACS chemical neuroscience, 2021 - ACS Publications
Cytokines and chemokines have diverse and pleiotropic functions in peripheral tissues and
in the brain. Recent studies uncovered a novel family of neuron-derived secretory proteins …
in the brain. Recent studies uncovered a novel family of neuron-derived secretory proteins …
Regulation of habenular G-protein gamma 8 on learning and memory via modulation of the central acetylcholine system
Guanine nucleotide binding protein (G protein) gamma 8 (Gng8) is a subunit of G proteins
and expressed in the medial habenula (MHb) and interpeduncular nucleus (IPN). Recent …
and expressed in the medial habenula (MHb) and interpeduncular nucleus (IPN). Recent …
Neuronal survival factor TAFA2 suppresses apoptosis through binding to ADGRL1 and activating cAMP/PKA/CREB/BCL2 signaling pathway
H Liang, LY Tang, HY Ge, MM Chen, SY Lu, HX Zhang… - Life Sciences, 2023 - Elsevier
Aims TAFA2, a cytokine specifically expressed in the central nervous system, plays a vital
role in neuronal cell survival. TAFA2 deficiency has been correlated to various neurological …
role in neuronal cell survival. TAFA2 deficiency has been correlated to various neurological …
Potential therapeutic effects of NAMPT-Mediated NAD biosynthesis in depression in vivo
J Wang, R Sun, L Xia, X Zhu, Q Zhang, Y Ye - Brain Sciences, 2022 - mdpi.com
This study aimed to investigate the potential therapeutic effects of nicotinamide
phosphoribosyltransferase (NAMPT)-mediated adenine dinucleotide (NAD) biosynthesis in …
phosphoribosyltransferase (NAMPT)-mediated adenine dinucleotide (NAD) biosynthesis in …
Long-lasting and sex-dependent effects of late lactational maternal deprivation on socioemotional behaviors in adult mice
H Fang, J Li, L Lu, J Yang, H Feng, X Yin, S Wang… - Neuroscience …, 2023 - Elsevier
The lactation period is an important period for individual development and a sensitive period
for the behavioral phenotypes and plasticity of individual offspring. Early life experiences …
for the behavioral phenotypes and plasticity of individual offspring. Early life experiences …
The unique expression profile of FAM19A1 in the mouse brain and its association with hyperactivity, long-term memory and fear acquisition
Neurodevelopment and mature brain function are spatiotemporally regulated by various
cytokines and chemokines. The chemokine-like neuropeptide FAM19A1 is a member of …
cytokines and chemokines. The chemokine-like neuropeptide FAM19A1 is a member of …