Zebrafish as an animal model for biomedical research

TY Choi, TI Choi, YR Lee, SK Choe… - Experimental & Molecular …, 2021 - nature.com
Zebrafish have several advantages compared to other vertebrate models used in modeling
human diseases, particularly for large-scale genetic mutant and therapeutic compound …

Advances in zebrafish as a comprehensive model of mental disorders

L Wang, F Liu, Y Fang, J Ma, J Wang, L Qu… - Depression and …, 2023 - Wiley Online Library
As an important part in international disease, mental disorders seriously damage human
health and social stability, which show the complex pathogenesis and increasing incidence …

[HTML][HTML] Deorphanizing FAM19A proteins as pan-neurexin ligands with an unusual biosynthetic binding mechanism

AJ Khalaj, FH Sterky, A Sclip, J Schwenk… - Journal of Cell …, 2020 - rupress.org
Neurexins are presynaptic adhesion molecules that organize synapses by binding to
diverse trans-synaptic ligands, but how neurexins are regulated is incompletely understood …

Stress-induced changes in social dominance are scaled by AMPA-type glutamate receptor phosphorylation in the medial prefrontal cortex

MJ Park, BA Seo, B Lee, HS Shin, MG Kang - Scientific Reports, 2018 - nature.com
The establishment and maintenance of social dominance are critical for social stability and
the survival and health of individual animals. Stress lead to depression and a decrease in …

FAM19A (TAFA): An emerging family of neurokines with diverse functions in the central and peripheral nervous system

DC Sarver, X Lei, GW Wong - ACS chemical neuroscience, 2021 - ACS Publications
Cytokines and chemokines have diverse and pleiotropic functions in peripheral tissues and
in the brain. Recent studies uncovered a novel family of neuron-derived secretory proteins …

Regulation of habenular G-protein gamma 8 on learning and memory via modulation of the central acetylcholine system

H Lee, TI Choi, YM Kim, S Lee, B Han, IS Bak… - Molecular …, 2021 - nature.com
Guanine nucleotide binding protein (G protein) gamma 8 (Gng8) is a subunit of G proteins
and expressed in the medial habenula (MHb) and interpeduncular nucleus (IPN). Recent …

Neuronal survival factor TAFA2 suppresses apoptosis through binding to ADGRL1 and activating cAMP/PKA/CREB/BCL2 signaling pathway

H Liang, LY Tang, HY Ge, MM Chen, SY Lu, HX Zhang… - Life Sciences, 2023 - Elsevier
Aims TAFA2, a cytokine specifically expressed in the central nervous system, plays a vital
role in neuronal cell survival. TAFA2 deficiency has been correlated to various neurological …

Potential therapeutic effects of NAMPT-Mediated NAD biosynthesis in depression in vivo

J Wang, R Sun, L Xia, X Zhu, Q Zhang, Y Ye - Brain Sciences, 2022 - mdpi.com
This study aimed to investigate the potential therapeutic effects of nicotinamide
phosphoribosyltransferase (NAMPT)-mediated adenine dinucleotide (NAD) biosynthesis in …

Long-lasting and sex-dependent effects of late lactational maternal deprivation on socioemotional behaviors in adult mice

H Fang, J Li, L Lu, J Yang, H Feng, X Yin, S Wang… - Neuroscience …, 2023 - Elsevier
The lactation period is an important period for individual development and a sensitive period
for the behavioral phenotypes and plasticity of individual offspring. Early life experiences …

The unique expression profile of FAM19A1 in the mouse brain and its association with hyperactivity, long-term memory and fear acquisition

HJ Yong, N Ha, EB Cho, S Yun, H Kim, JI Hwang… - Scientific reports, 2020 - nature.com
Neurodevelopment and mature brain function are spatiotemporally regulated by various
cytokines and chemokines. The chemokine-like neuropeptide FAM19A1 is a member of …