Biomechanical, biophysical and biochemical modulators of cytoskeletal remodelling and emergent stem cell lineage commitment

VDL Putra, KA Kilian, ML Knothe Tate - Communications Biology, 2023 - nature.com
Across complex, multi-time and-length scale biological systems, redundancy confers
robustness and resilience, enabling adaptation and increasing survival under dynamic …

Actin cytoskeletal dynamics in single-cell wound repair

ML Ebstrup, C Dias, ASB Heitmann, SL Sønder… - International Journal of …, 2021 - mdpi.com
The plasma membrane protects the eukaryotic cell from its surroundings and is essential for
cell viability; thus, it is crucial that membrane disruptions are repaired quickly to prevent …

Mitochondrial fragmentation enables localized signaling required for cell repair

A Horn, S Raavicharla, S Shah, D Cox… - Journal of Cell …, 2020 - rupress.org
Plasma membrane injury can cause lethal influx of calcium, but cells survive by mounting a
polarized repair response targeted to the wound site. Mitochondrial signaling within seconds …

[HTML][HTML] Plasma membrane wound repair is characterized by extensive membrane lipid and protein rearrangements in vascular endothelial cells

APK Ashraf, V Gerke - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2021 - Elsevier
Vascular endothelial cells are subject to mechanical stress resulting from blood flow and
interactions with leukocytes. Stress occurs at the apical, vessel-facing cell surface and leads …

Dynamics of actin cytoskeleton and their signaling pathways during cellular wound repair

S Yumura, MSU Talukder, MS Pervin, MIO Tanvir… - Cells, 2022 - mdpi.com
The repair of wounded cell membranes is essential for cell survival. Upon wounding, actin
transiently accumulates at the wound site. The loss of actin accumulation leads to cell death …

Cross-talk-dependent cortical patterning of Rho GTPases during cell repair

A Moe, W Holmes, AE Golding, J Zola… - Molecular biology of …, 2021 - Am Soc Cell Biol
Rho GTPases such as Rho, Rac, and Cdc42 are important regulators of the cortical
cytoskeleton in processes including cell division, locomotion, and repair. In these processes …

The cellular response to plasma membrane disruption for nanomaterial delivery

G Houthaeve, SC De Smedt, K Braeckmans… - Nano …, 2022 - Springer
Delivery of nanomaterials into cells is of interest for fundamental cell biological research as
well as for therapeutic and diagnostic purposes. One way of doing so is by physically …

Wound Repair of the Cell Membrane: Lessons from Dictyostelium Cells

S Yumura - Cells, 2024 - mdpi.com
The cell membrane is frequently subjected to damage, either through physical or chemical
means. The swift restoration of the cell membrane's integrity is crucial to prevent the leakage …

Tension modulation of actomyosin ring assembly and RhoGTPases activity: Perspectives from the Xenopus oocyte wound healing model

T Kato, L Ghadban, E Boucher, CA Mandato - Cytoskeleton, 2021 - Wiley Online Library
Cells are remarkably resilient structures; they are able to recover from injuries to their
plasma membrane (PM) and cytoskeleton that would normally constitute existential threats …