Extracellular vesicles from organoids and 3D culture systems

S Abdollahi - Biotechnology and bioengineering, 2021 - Wiley Online Library
When discovered, extracellular vesicles (EVs) such as exosomes were thought of as junk
carriers and a means by which the cell disposed of its waste material. Over the years, the …

Bioengineering the oxygen-deprived tumor microenvironment within a three-dimensional platform for studying tumor-immune interactions

S Bhattacharya, K Calar, C Evans… - … in bioengineering and …, 2020 - frontiersin.org
Oxygen deprivation within tumors is one of the most prevalent causes of resilient cancer cell
survival and increased immune evasion in breast cancer (BCa). Current in vitro models do …

Hydrogel-assisted 3D model to investigate the osteoinductive potential of MC3T3-derived extracellular vesicles

K Holkar, V Kale, G Ingavle - ACS biomaterials science & …, 2021 - ACS Publications
Effective and rapid regeneration of bone defects often pose substantial challenges in severe
accidental injuries and disabilities occurring due to diseases and/or advanced age …

Analysis of dual class I histone deacetylase and lysine demethylase inhibitor domatinostat (4SC-202) on growth and cellular and genomic landscape of atypical …

MM Hoffman, JS Zylla, S Bhattacharya, K Calar… - Cancers, 2020 - mdpi.com
Central nervous system atypical teratoid/rhabdoid tumors (ATRTs) are rare and aggressive
tumors with a very poor prognosis. Current treatments for ATRT include resection of the …

Human plasma-derived 3D cultures model breast cancer treatment responses and predict clinically effective drug treatment concentrations

K Calar, S Plesselova, S Bhattacharya, M Jorgensen… - Cancers, 2020 - mdpi.com
Lack of efficacy and a low overall success rate of phase I-II clinical trials are the most
common failures when it comes to advancing cancer treatment. Current drug sensitivity …

Computational molecular profiling of exosomes to monitor hypoxia in In vitro 3D culture systems for tissue engineering and tumour angiogenesis

KA Mathew, BK Madathil - 2023 - indianjournals.com
Molecular profiling is increasingly explored in biology as a diagnostic, prognostic, and
discerning tool. Gene and protein expression signatures generated using bioinformatics …