Over the past few years, several groups have identified new genes that are transcriptionally
induced downstream of type I interferon (IFN) signalling and that inhibit infection by …

ABSTRACT A major component of the protective antiviral host defense is contributed by the
intracellular actions of the proteins encoded by interferon-stimulated genes (ISGs); among …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) variants govern
transmissibility, responsiveness to vaccination, and disease severity. In a screen for new …

The ongoing Zika virus (ZIKV) epidemic and unexpected clinical outcomes, including
Guillain-Barré syndrome and birth defects, has brought an urgent need for animal models …

Long noncoding RNAs (lncRNAs) modulate various biological processes, but their role in
host antiviral responses is largely unknown. Here we identify a lncRNA as a key regulator of …

Highlights•Individual ISGs have measurable phenotypes in vivo.•ISGs control viral
pathogenesis through a variety of mechanisms.•ISG effects in vivo are often virus-specific …

The sudden emergence of severe acute respiratory syndrome coronavirus (SARS-CoV) in
2002 and, more recently, Middle Eastern respiratory syndrome CoV (MERS-CoV) …

Secretion of interferons (IFNs) from virus-infected cells is a hallmark of host antiviral
immunity and in fact, IFNs exert their antiviral activities through the induction of antiviral …

West Nile virus (WNV) is an emerging flavivirus capable of infecting the central nervous
system (CNS) and mediating neuronal cell death and tissue destruction. The processes that …

Viruses that generate capped RNA lacking 2′ O methylation on the first ribose are severely
affected by the antiviral activity of Type I interferons. We used proteome-wide affinity …