Accurate control of gene expression is essential for normal development and dysregulation
of transcription underpins cancer onset and progression. Similar to cell cycle regulation …

RUNX1 is a member of the core-binding factor family of transcription factors and is
indispensable for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is …

Acute myeloid leukemia (AML) is a heterogeneous disease caused by a variety of
alterations in transcription factors, epigenetic regulators and signaling molecules. To …

Defects in chromatin modifiers and remodelers have been described both for hematological
and solid malignancies, corroborating and strengthening the role of epigenetic aberrations …

Metazoan development involves the successive activation and silencing of specific gene
expression programs and is driven by tissue-specific transcription factors programming the …

One of the most studied transcription factors in hematopoiesis is the leucine zipper CCAAT-
enhancer binding protein α (C/EBPα), which is mainly involved in cell fate decisions for …

Oncogenic transcription factors such as the leukemic fusion protein RUNX1/ETO, which
drives t (8; 21) acute myeloid leukemia (AML), constitute cancer-specific but highly …

Abstract Acute Myeloid Leukemia (AML) is caused by multiple mutations which dysregulate
growth and differentiation of myeloid cells. Cells adopt different gene regulatory networks …

Abstract The chromosomal translocation t (8; 21) and the resulting oncofusion gene
AML1/ETO have long served as a prototypical genetic lesion to model and understand …

Summary The t (4; 11)(q21; q23) fuses mixed-lineage leukemia (MLL) to AF4, the most
common MLL-fusion partner. Here we show that MLL fused to murine Af4, highly conserved …