RNA‐dependent RNA polymerase of SARS‐CoV‐2 as a therapeutic target
Y Wang, V Anirudhan, R Du, Q Cui… - Journal of medical …, 2021 - Wiley Online Library
The global pandemic caused by severe acute respiratory syndrome coronavirus‐2 (SARS‐
CoV‐2), named coronavirus disease 2019, has infected more than 8.9 million people …
CoV‐2), named coronavirus disease 2019, has infected more than 8.9 million people …
The mechanism of genome replication and transcription in bunyaviruses
Bunyaviruses are negative sense, single-strand RNA viruses that infect a wide range of
vertebrate, invertebrate and plant hosts. WHO lists three bunyavirus diseases as priority …
vertebrate, invertebrate and plant hosts. WHO lists three bunyavirus diseases as priority …
Nucleosides and emerging viruses: A new story
V Roy, LA Agrofoglio - Drug Discovery Today, 2022 - Elsevier
With several US Food and Drug Administration (FDA)-approved drugs and high barriers to
resistance, nucleoside and nucleotide analogs remain the cornerstone of antiviral therapies …
resistance, nucleoside and nucleotide analogs remain the cornerstone of antiviral therapies …
Structures of the Mononegavirales Polymerases
B Liang - Journal of Virology, 2020 - Am Soc Microbiol
Mononegavirales, known as nonsegmented negative-sense (NNS) RNA viruses, are a class
of pathogenic and sometimes deadly viruses that include rabies virus (RABV), human …
of pathogenic and sometimes deadly viruses that include rabies virus (RABV), human …
Point mutations at specific sites of the nsp12–nsp8 interface dramatically affect the RNA polymerization activity of SARS-CoV-2
C Ferrer-Orta, S Vázquez-Monteagudo… - Proceedings of the …, 2024 - pnas.org
In a recent characterization of the Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) variability present in 30 diagnostic samples from patients of the first COVID …
(SARS-CoV-2) variability present in 30 diagnostic samples from patients of the first COVID …
RNA synthesis and capping by non-segmented negative strand RNA viral polymerases: lessons from a prototypic virus
Non-segmented negative strand (NNS) RNA viruses belonging to the order
Mononegavirales are highly diversified eukaryotic viruses including significant human …
Mononegavirales are highly diversified eukaryotic viruses including significant human …
The SARS-CoV nsp12 polymerase active site is tuned for large-genome replication
G Campagnola, V Govindarajan, A Pelletier… - Journal of …, 2022 - Am Soc Microbiol
Positive-strand RNA viruses replicate their genomes using virally encoded RNA-dependent
RNA polymerases (RdRP) with a common active-site structure and closure mechanism upon …
RNA polymerases (RdRP) with a common active-site structure and closure mechanism upon …
The human gut Virome and its relationship with nontransmissible chronic diseases
S Ezzatpour, AC Mondragon Portocarrero… - Nutrients, 2023 - mdpi.com
The human gastrointestinal tract contains large communities of microorganisms that are in
constant interaction with the host, playing an essential role in the regulation of several …
constant interaction with the host, playing an essential role in the regulation of several …
Supramolecular arrangement of the full-length Zika virus NS5
Zika virus (ZIKV), a member of the Flavivirida e family, has emerged as a major public health
threat, since ZIKV infection has been connected to microcephaly and other neurological …
threat, since ZIKV infection has been connected to microcephaly and other neurological …
Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes
Bunyavirales is an order of segmented negative-strand RNA viruses comprising several life-
threatening pathogens against which no effective treatment is currently available …
threatening pathogens against which no effective treatment is currently available …