In the 50 years since Andreas Rett first described the syndrome that came to bear his name,
and is now known to be caused by a mutation in the methyl-CpG-binding protein 2 (MECP2) …

Two severe, progressive neurological disorders characterized by intellectual disability,
autism, and developmental regression, Rett syndrome and MECP2 duplication syndrome …

Rett syndrome is a rare, genetic neurodevelopmental disorder. Trofinetide is a synthetic
analog of glycine–proline–glutamate, the N-terminal tripeptide of the insulin-like growth …

Objective To determine safety, tolerability, and pharmacokinetics of trofinetide and evaluate
its efficacy in female children/adolescents with Rett syndrome (RTT), a debilitating …

Introduction Rett syndrome (RTT) is a debilitating neurodevelopmental disorder with no
approved treatments. Trofinetide is a synthetic analog of glycine–proline–glutamate, the N …

Stress plays a key role in pathogenesis of anxiety and depression. Animal models of these
disorders are widely used in behavioral neuroscience to explore stress-evoked brain …

Rett syndrome (RTT) is a unique neurodevelopmental disorder that primarily affects females
resulting in severe cognitive and physical disabilities. Despite the commendable collective …

Background Early development appears normal in Rett syndrome (OMIM# 312750) and may
be more apparent than real. A major purpose of the Rett Syndrome (RTT) Natural History …

Over 90% of Rett syndrome (RTT) cases have a mutation in the X-linked gene encoding
methyl CpG binding-protein 2 (MeCP2). A mouse model that reprises clinical manifestations …

Background While behavioural abnormalities are fundamental features of Rett syndrome
(RTT), few studies have examined the RTT behavioural phenotype. Most of these reports …