Network Medicine applies network science approaches to investigate disease
pathogenesis. Many different analytical methods have been used to infer relevant molecular …

As invaluable as the standard 2-dimensional (2D) monolayer in vitro cell culture system has
been, there is increasing evidence that 3-dimensional (3D) non-adherent conditions are …

Sex differences manifest in many diseases and may drive sex-specific therapeutic
responses. To understand the molecular basis of sex differences, we evaluated sex-biased …

Network medicine is an emerging area of research dealing with molecular and genetic
interactions, network biomarkers of disease, and therapeutic target discovery. Large-scale …

Understanding sex differences in colon cancer is essential to advance disease prevention,
diagnosis, and treatment. Males have a higher risk of developing colon cancer and a lower …

Gene regulation plays a fundamental role in shaping tissue identity, function, and response
to perturbation. Regulatory processes are controlled by complex networks of interacting …

Human biology is rooted in highly specialized cell types programmed by a common
genome, 98% of which is outside of genes. Genetic variation in the enormous noncoding …

Lung cancer (LC) represents most of the cancer incidences in the world. There are many
types of LC, but Lung Adenocarcinoma (LUAD) is the most common type. Although RNA-seq …

Regulatory interactions mediated by transcription factors (TFs) make up complex networks
that control cellular behavior. Fully understanding these gene regulatory networks (GRNs) …

The biological processes that drive cellular function can be represented by a complex
network of interactions between regulators (transcription factors) and their targets (genes). A …