Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic
B Blasco, D Leroy, DA Fidock - Nature medicine, 2017 - nature.com
The global adoption of artemisinin-based combination therapies (ACTs) in the early 2000s
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …
heralded a new era in effectively treating drug-resistant Plasmodium falciparum malaria …
Antimalarial drug resistance: a threat to malaria elimination
Increasing antimalarial drug resistance once again threatens effective antimalarial drug
treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are …
treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are …
[HTML][HTML] Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum
The mechanism of action of artemisinin and its derivatives, the most potent of the anti-
malarial drugs, is not completely understood. Here we present an unbiased chemical …
malarial drugs, is not completely understood. Here we present an unbiased chemical …
A molecular marker of artemisinin-resistant Plasmodium falciparum malaria
F Ariey, B Witkowski, C Amaratunga, J Beghain… - Nature, 2014 - nature.com
Plasmodium falciparum resistance to artemisinin derivatives in southeast Asia threatens
malaria control and elimination activities worldwide. To monitor the spread of artemisinin …
malaria control and elimination activities worldwide. To monitor the spread of artemisinin …
[HTML][HTML] Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome
Artemisinin and its derivatives (collectively referred to as ARTs) rapidly reduce the parasite
burden in Plasmodium falciparum infections, and antimalarial control is highly dependent on …
burden in Plasmodium falciparum infections, and antimalarial control is highly dependent on …
Molecular Mechanisms of Drug Resistance in Plasmodium falciparum Malaria
Understanding and controlling the spread of antimalarial resistance, particularly to
artemisinin and its partner drugs, is a top priority. Plasmodium falciparum parasites resistant …
artemisinin and its partner drugs, is a top priority. Plasmodium falciparum parasites resistant …
Artemisinin action and resistance in Plasmodium falciparum
The worldwide use of artemisinin-based combination therapies (ACTs) has contributed in
recent years to a substantial reduction in deaths resulting from Plasmodium falciparum …
recent years to a substantial reduction in deaths resulting from Plasmodium falciparum …
Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance
Artemisinin resistance in Plasmodium falciparum threatens global efforts to control and
eliminate malaria. Polymorphisms in the kelch domain–carrying protein K13 are associated …
eliminate malaria. Polymorphisms in the kelch domain–carrying protein K13 are associated …
Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies
B Witkowski, C Amaratunga, N Khim… - The Lancet infectious …, 2013 - thelancet.com
Summary Background Artemisinin resistance in Plasmodium falciparum lengthens parasite
clearance half-life during artemisinin monotherapy or artemisinin-based combination …
clearance half-life during artemisinin monotherapy or artemisinin-based combination …
A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malaria parasites
J Birnbaum, S Scharf, S Schmidt, E Jonscher… - Science, 2020 - science.org
Artemisinin and its derivatives (ARTs) are the frontline drugs against malaria, but resistance
is jeopardizing their effectiveness. ART resistance is mediated by mutations in the parasite's …
is jeopardizing their effectiveness. ART resistance is mediated by mutations in the parasite's …