Systemic lupus erythematosus (SLE) is a complex autoimmune disease with multisystem
involvement. It is multifactorial and involves epigenetic, genetic, ecological, and …

Type I interferons (IFNs) play essential roles in establishing and modulating host defense
against microbial infection via induction of IFN-stimulated genes (ISGs) through Janus …

Intestinal dysbiosis, characterized by a reduced Firmicutes/Bacteroidetes ratio, has been
reported in systemic lupus erythematosus (SLE) patients. In this study, in vitro cultures …

Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the
loss of tolerance to nuclear self antigens, the production of pathogenic autoantibodies and …

Interferons (IFNs) were discovered as cytokines induced during and protecting from viral
infection. They have been documented to play essential roles in numerous physiological …

Systemic lupus erythematosus (SLE) is a multifactorial autoimmune disorder. The study of
diverse mouse models of lupus has provided clues to the etiology of SLE. Spontaneous …

Plasmacytoid dendritic cells (pDCs) have long been implicated in the pathogenesis of lupus.
However, this conclusion has been largely based on a correlative link between the copious …

Over the past decades the notion of 'inflammation'has been extended beyond the original
hallmarks of rubor (redness), calor (heat), tumor (swelling) and dolor (pain) described by …

Long noncoding RNAs (lncRNAs) involved in the regulation of antiviral innate immune
responses need to be further identified. By functionally screening the lncRNAs in …

The term interferon describes a family of proteins consisting of three major types (I, II, III)
which differ in their primary protein sequences, cognate receptors, genetic loci, and cell …