Astrocyte function from information processing to cognition and cognitive impairment

M Santello, N Toni, A Volterra - Nature neuroscience, 2019 - nature.com
Astrocytes serve important roles that affect recruitment and function of neurons at the local
and network levels. Here we review the contributions of astrocyte signaling to synaptic …

Physiology of astroglia

A Verkhratsky, M Nedergaard - Physiological reviews, 2018 - journals.physiology.org
Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

[HTML][HTML] Specialized astrocytes mediate glutamatergic gliotransmission in the CNS

R de Ceglia, A Ledonne, DG Litvin, BL Lind, G Carriero… - Nature, 2023 - nature.com
Multimodal astrocyte–neuron communications govern brain circuitry assembly and function.
For example, through rapid glutamate release, astrocytes can control excitability, plasticity …

[HTML][HTML] Astrocytic activation generates de novo neuronal potentiation and memory enhancement

A Adamsky, A Kol, T Kreisel, A Doron… - Cell, 2018 - cell.com
Astrocytes respond to neuronal activity and were shown to be necessary for plasticity and
memory. To test whether astrocytic activity is also sufficient to generate synaptic potentiation …

Astrocyte calcium signaling: the third wave

N Bazargani, D Attwell - Nature neuroscience, 2016 - nature.com
The discovery that transient elevations of calcium concentration occur in astrocytes, and
release'gliotransmitters' which act on neurons and vascular smooth muscle, led to the idea …

Diversity and specificity of astrocyte–neuron communication

CA Durkee, A Araque - Neuroscience, 2019 - Elsevier
Astrocytes are emerging as important players in synaptic function, and, consequently, on
brain function and animal behavior. According to the Tripartite Synapse concept, astrocytes …

[HTML][HTML] Gliotransmitters travel in time and space

A Araque, G Carmignoto, PG Haydon, SHR Oliet… - Neuron, 2014 - cell.com
The identification of the presence of active signaling between astrocytes and neurons in a
process termed gliotransmission has caused a paradigm shift in our thinking about brain …

G-protein-coupled receptors in astrocyte–neuron communication

P Kofuji, A Araque - Neuroscience, 2021 - Elsevier
Astrocytes, a major type of glial cell, are known to play key supportive roles in brain function,
contributing to ion and neurotransmitter homeostasis, maintaining the blood–brain barrier …

Ca2+ signaling in astrocytes from Ip3r2−/− mice in brain slices and during startle responses in vivo

R Srinivasan, BS Huang, S Venugopal… - Nature …, 2015 - nature.com
Intracellular Ca2+ signaling is considered to be important for multiple astrocyte functions in
neural circuits. However, mice devoid of inositol triphosphate type 2 receptors (IP3R2) …

[HTML][HTML] Calcium imaging reveals glial involvement in transcranial direct current stimulation-induced plasticity in mouse brain

H Monai, M Ohkura, M Tanaka, Y Oe, A Konno… - Nature …, 2016 - nature.com
Transcranical direct current stimulation (tDCS) is a treatment known to ameliorate various
neurological conditions and enhance memory and cognition in humans. tDCS has gained …