[HTML][HTML] Recent advances in management of COVID-19: A review

S Mouffak, Q Shubbar, E Saleh, R El-Awady - Biomedicine & …, 2021 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused and is still causing
significant mortality and economic consequences all over the globe. As of today, there are …

Fluorine in medicinal chemistry: in perspective to COVID-19

C Zhang - ACS omega, 2022 - ACS Publications
Over two years into the outbreak of COVID-19, the quest for effective and economical drugs
has become starkly clear to reduce the risk of progression of coronavirus disease. A number …

Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro

SM Fred, S Kuivanen, H Ugurlu… - Frontiers in …, 2022 - frontiersin.org
Repurposing of currently available drugs is a valuable strategy to tackle the consequences
of COVID-19. Recently, several studies have investigated the effect of psychoactive drugs on …

Antiviral and anti-inflammatory activities of fluoxetine in a SARS-CoV-2 infection mouse model

D Péricat, SA Leon-Icaza, M Sanchez Rico… - International Journal of …, 2022 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic continues to cause significant
morbidity and mortality worldwide. Since a large portion of the world's population is currently …

Beyond vaccines: clinical status of prospective COVID-19 therapeutics

S Kumar, DM Çalışkan, J Janowski, A Faist… - Frontiers in …, 2021 - frontiersin.org
Since November 2019 the SARS-CoV-2 pandemic has caused nearly 200 million infection
and more than 4 million deaths globally (Updated information from the World Health …

Fluoxetine can inhibit SARS-CoV-2 in vitro

A Dechaumes, MP Nekoua, S Belouzard, F Sane… - Microorganisms, 2021 - mdpi.com
An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) resulted in
the coronavirus disease pandemic, drastically affecting global health and economy. Though …

Selective serotonin reuptake inhibitor (SSRI) antidepressants reduce COVID-19 infection: prospects for use

VS Foletto, TF Da Rosa, MB Serafin… - European journal of clinical …, 2022 - Springer
Purpose The absence of specific treatments for COVID-19 leads to an intense global effort in
the search for new therapeutic interventions and better clinical outcomes for patients. This …

Head-to-head comparison of sedation and somnolence among 37 antipsychotics in schizophrenia, bipolar disorder, major depression, autism spectrum disorders …

AR Eugene, B Eugene, M Masiak… - Frontiers in …, 2021 - frontiersin.org
Objective: Antipsychotic compounds are known to induce sedation somnolence and have
expanded clinical indications beyond schizophrenia to regulatory approval in bipolar …

Low-dose fluvoxamine modulates endocytic trafficking of SARS-CoV-2 spike protein: a potential mechanism for anti-COVID-19 protection by antidepressants

OO Glebov - Frontiers in Pharmacology, 2021 - frontiersin.org
Commonly prescribed antidepressants may be associated with protection against severe
COVID-19. The mechanism of their action in this context, however, remains unknown. Here, I …

Antiviral efficacy of fluoxetine in early symptomatic COVID-19: An open-label, randomised, controlled, adaptive platform trial (PLATCOV)

P Jittamala, S Boyd, WHK Schilling, JA Watson… - medRxiv, 2024 - medrxiv.org
Background The selective serotonin reuptake inhibitors (SSRIs) fluoxetine and fluvoxamine
were repurposed for the treatment of early COVID-19 based on their antiviral activity in vitro …