Osteosarcoma is a primary malignant tumor that tends to threaten children and adolescents,
and the 5-year event-free survival rate has not improved significantly in the past three …

Despite an increasing arsenal of anticancer therapies, many patients continue to have poor
outcomes due to the therapeutic failures and tumor relapses. Indeed, the clinical efficacy of …

Simple Summary Osteosarcoma is the most common cancer of the bone for children and
adolescents. Although chemotherapy regimens have been widely available and effective for …

2D culture as a model for drug testing often turns to be clinically futile. Therefore, 3D cultures
(3Ds) show potential to better model responses to drugs observed in vivo. In preliminary …

In order to adapt to a higher proliferative rate and an increased demand for energy sources,
cancer cells rewire their metabolic pathways, a process currently recognized as a hallmark …

Background Solid tumors subjected to intermittent hypoxia are characterized by resistance
to chemotherapy and immune-killing by effector T-lymphocytes, particularly tumor-infiltrating …

Mevalonate pathway is a highly conserved pathway that produces isoprenoids and
cholesterol, and it is often increased in cancer cells. Cholesterol, upstream metabolites …

Phosphorylation of proteins is reversibly controlled by the kinases and phosphatases in
many posttranslational regulation patterns. Protein phosphatase 5 (PPP5C) is a …

Simple Summary The pathogenesis of osteosarcoma relies on complex interactions
between developing cancer and surrounding tissue, which includes proteins of the …

Improving the prognosis and cure rate of HGOSs (high-grade osteosarcomas) is an absolute
need. Immune-based treatment approaches have been increasingly taken into …