Advancing the understanding of the tablet disintegration phenomenon–an update on recent studies

A Berardi, L Bisharat, J Quodbach, SA Rahim… - International Journal of …, 2021 - Elsevier
Disintegration is the de-aggregation of particles within tablets upon exposure to aqueous
fluids. Being an essential step in the bioavailability cascade, disintegration is a fundamental …

Exploring the performance-controlling tablet disintegration mechanisms for direct compression formulations

N Maclean, E Walsh, M Soundaranathan… - International Journal of …, 2021 - Elsevier
The design and manufacture of tablets is a challenging process due to the complex
interrelationships between raw material properties, the manufacturing settings and the tablet …

Hyperlipidemia control using the innovative association of lupin proteins and chitosan and α-cyclodextrin dietary fibers: food supplement formulation, molecular …

E Elmowafy, L Pavoni, DR Perinelli, M Tiboni… - … Food Research and …, 2022 - Springer
A dietary supplement potentially employed for the treatment and/or prevention of
hyperlipidemia was developed. The proposed product is composed of a combination of …

[HTML][HTML] The impact of lactose type on disintegration: An integral study on porosity and polymorphism

PHM Janssen, A Berardi, JH Kok, AW Thornton… - European Journal of …, 2022 - Elsevier
Besides factors such as disintegrant and lubricant, the raw material properties of filler
excipients can have an impact on the disintegration behavior of a tablet. The current …

Disintegrant selection in hydrophobic tablet formulations

S Bauhuber, G Warnke, A Berardi - Journal of Pharmaceutical Sciences, 2021 - Elsevier
The hydrophobicity of poorly soluble drugs can delay tablets disintegration. We probed here
the influence of different disintegrants on the disintegration of challenging hydrophobic …

[HTML][HTML] Application of co-processed excipients for developing fast disintegrating tablets: A review

S Jain, S Kaur, R Rathi, U Nagaich… - Polymers in …, 2023 - polimery.umw.edu.pl
The introduction of tablet dosage forms has brought a revolution in the pharmaceutical drug
delivery system. Different forms of tablets have been developed based on the target site, the …

Alginates as tablet disintegrants: Understanding disintegration mechanisms and defining ranges of applications

A Berardi, S Bauhuber, O Sawafta, G Warnke - International Journal of …, 2021 - Elsevier
Alginates are biopolymers that have been investigated for their use in food and medical
fields. Minimal information is available regarding their potential application as tablet …

Innovative method for longer effective corrosion inhibition time: controlled release oil palm empty fruit bunch hemicellulose inhibitor tablet

NIN Haris, S Sobri, YA Yusof, NK Kassim - Materials, 2021 - mdpi.com
This study aims to develop a controlled release oil palm empty fruit bunch hemicellulose
(EFB-H) inhibitor tablet for mild steel in 1 M HCl. As plant extracts tend to deteriorate at …

Temperature: an overlooked factor in tablet disintegration

S Basaleh, L Bisharat, M Cespi, A Berardi - European Journal of …, 2020 - Elsevier
Disintegration is the first event in the bioavailability cascade after the ingestion of immediate
release tablets. Although the influence of various physico-chemical parameters of media on …

Formulation and in vitro evaluation of pellets containing sulfasalazine and caffeine to verify ileo-colonic drug delivery

A Broesder, SY Bircan, AB De Waard, AC Eissens… - Pharmaceutics, 2021 - mdpi.com
The ColoPulse coating is a pH-dependent coating that can be used to target drug release to
the ileo-colonic region. ColoPulse coated tablets and capsules have demonstrated their …