[HTML][HTML] ERK1/2 Inhibition via the Oral Administration of Tizaterkib Alleviates Noise-Induced Hearing Loss While Tempering down the Immune Response

RD Lutze, MA Ingersoll, A Thotam, A Joseph… - International Journal of …, 2024 - mdpi.com
Noise-induced hearing loss (NIHL) is a major cause of hearing impairment and is linked to
dementia and mental health conditions, yet no FDA-approved drugs exist to prevent it …

Trametinib, a MEK1/2 Inhibitor, Protects Mice from Cisplatin-and Noise-Induced Hearing Loss

RD Lutze, MA Ingersoll, RG Kelmann, T Teitz - Pharmaceuticals, 2024 - mdpi.com
Hearing loss is one of the most common types of disability; however, there is only one FDA-
approved drug to prevent any type of hearing loss. Treatment with the highly effective …

[HTML][HTML] Oseltamivir (Tamiflu), a commonly prescribed antiviral drug, mitigates hearing loss in mice

EJ Sailor‐Longsworth, RD Lutze… - Clinical and …, 2024 - pmc.ncbi.nlm.nih.gov
Dear Editor, Hearing loss affects up to 10% of people worldwide and therapeutic
interventions are desperately needed. Noise exposure and chemotherapy treatments are …

[HTML][HTML] Exploring the bioactive ingredients of three traditional Chinese medicine formulas against age-related hearing loss through network pharmacology and …

W Shi, Q Zhao, H Gao, Y Yang, Z Tan, N Li… - Naunyn-Schmiedeberg's …, 2024 - Springer
Traditional Chinese medicine (TCM) formulas, including the Er-Long-Zuo-Ci pill, Tong-Qiao-
Er-Long pill, and Er-Long pill, have long been utilized in China for managing age-related …

FDA-Approved MEK1/2 Inhibitor, Trametinib, Protects Mice from Cisplatin and Noise-Induced Hearing Loss

RD Lutze, MA Ingersoll, RG Kelmann, T Teitz - bioRxiv, 2024 - biorxiv.org
Hearing loss is one of the most common types of disability; however, there is only one FDA-
approved drug to prevent any type of hearing loss. Treatment with the highly effective …