Therapeutically harnessing extracellular vesicles
The field of extracellular vesicle (EV) research has developed rapidly over the last decade
from the study of fundamental biology to a subject of significant clinical relevance. The …
from the study of fundamental biology to a subject of significant clinical relevance. The …
Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?
M Kou, L Huang, J Yang, Z Chiang, S Chen, J Liu… - Cell Death & …, 2022 - nature.com
Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone
marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and …
marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and …
MSC exosome as a cell-free MSC therapy for cartilage regeneration: implications for osteoarthritis treatment
Mesenchymal stem cell (MSC) therapies have demonstrated efficacy in cartilage repair in
animal and clinical studies. The efficacy of MSC-based therapies which was previously …
animal and clinical studies. The efficacy of MSC-based therapies which was previously …
Biomaterials in guided bone and tissue regenerations: an update
Purpose. Guided tissue reconstruction can be performed to restore the supporting structure
of a previously lost tooth, which, in addition to maintaining beauty, preserves the function of …
of a previously lost tooth, which, in addition to maintaining beauty, preserves the function of …
Paracrine mechanisms of mesenchymal stem cells in tissue repair
M Gnecchi, P Danieli, G Malpasso… - Mesenchymal Stem Cells …, 2016 - Springer
Tissue regeneration from transplanted mesenchymal stromal cells (MSC) either through
transdifferentiation or cell fusion was originally proposed as the principal mechanism …
transdifferentiation or cell fusion was originally proposed as the principal mechanism …
Mesenchymal stem cell exosomes
MSCs are an extensively used cell type in clinical trials today. The initial rationale for their
clinical testing was based on their differentiation potential. However, the lack of correlation …
clinical testing was based on their differentiation potential. However, the lack of correlation …
[HTML][HTML] Mesenchymal stromal/stem cell-derived extracellular vesicles in tissue repair: challenges and opportunities
S Varderidou-Minasian, MJ Lorenowicz - Theranostics, 2020 - ncbi.nlm.nih.gov
Mesenchymal stem/stromal cells (MSCs) are important players in tissue homeostasis and
regeneration owing to their immunomodulatory potential and release of trophic factors that …
regeneration owing to their immunomodulatory potential and release of trophic factors that …
[HTML][HTML] Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and …
We have previously identified exosomes as the paracrine factor secreted by mesenchymal
stem cells. Recently, we found that the key features of reperfusion injury, namely loss of …
stem cells. Recently, we found that the key features of reperfusion injury, namely loss of …
[HTML][HTML] Bacterial extracellular vesicles-based therapeutic strategies for bone and soft tissue tumors therapy
H Liu, H Zhang, Y Han, Y Hu, Z Geng, J Su - Theranostics, 2022 - ncbi.nlm.nih.gov
Bone and soft tissue tumors are complex mesenchymal neoplasms that seriously endanger
human health. Over the past decade, the relationship between microorganisms and human …
human health. Over the past decade, the relationship between microorganisms and human …
Mesenchymal stem cells secrete immunologically active exosomes
Mesenchymal stem cells (MSCs) have been shown to secrete exosomes that are
cardioprotective. Here, we demonstrated that MSC exosome, a secreted membrane vesicle …
cardioprotective. Here, we demonstrated that MSC exosome, a secreted membrane vesicle …