Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …

The prevalence of neurodegenerative disease has increased significantly in recent years,
and with a rapidly aging global population, this trend is expected to continue. These …

With the increasing understanding of various biological functions mediated by reactive
oxygen species (ROS) in the immune system, a number of studies have been designed to …

Background Pain is generally concomitant with an inflammatory reaction at the site where
the nociceptive fibers are activated. Rodent studies suggest that a sterile meningeal …

The present article provides a detailed concept of the role of NLRP3 inflammasome in the
pathophysiology of depression-like chronic diseases where inflammation and release of …

Autoinflammatory diseases (AIDs) represent a rare and heterogeneous group of disorders
characterized by recurrent episodes of inflammation and a broad range of clinical …

Inflammasomes are assembled by innate immune sensors that cells employ to detect a
range of danger signals and respond with pro‐inflammatory signalling. Inflammasomes …

Many aspects of cell homeostasis and integrity are maintained by the nucleotide-binding
oligomerization domain (NOD)-like receptor (NLR) family pyrin domain-containing 3 …

Cerebral ischemia reperfusion injury is a debilitating medical condition, currently with only a
limited amount of therapies aimed at protecting the cerebral parenchyma. Micro RNAs …

Inflammatory bowel disease (IBD) remains a persistent health problem with a global burden
surging over 6.8 million cases currently. Clinical pathology of IBD is complicated; however …