Overview of diagnosis and drug treatments of anxiety disorders

DJ Nutt - CNS spectrums, 2005 - cambridge.org
Anxiety disorders are common and often disabling. They fall into five main categories: panic
disorder, social anxiety disorder, generalized anxiety disorder, obsessive-compulsive …

Venlafaxine extended release (ER) in the treatment of generalised anxiety disorder: twenty-four-week placebo-controlled dose-ranging study

C Allgulander, D Hackett, E Salinas - The British Journal of …, 2001 - cambridge.org
BackgroundGeneralised anxiety disorder (GAD) has received less study than other anxiety
disorders, particularly its long-term treatment. AimsTo assess the efficacy and safety of …

Ovarian steroid regulation of monoamine oxidase-A and B mRNAs in the macaque dorsal raphe and hypothalamic nuclei

C Gundlah, NZ Lu, CL Bethea - Psychopharmacology, 2002 - Springer
Rationale: The serotonin neural system plays a pivotal role in mood, affective regulation and
integrative cognition, as well as numerous autonomic functions. We have shown that ovarian …

Differential physiological effects of a low dose and high doses of venlafaxine in major depression

G Debonnel, É Saint-André, C Hébert… - International Journal …, 2007 - academic.oup.com
Venlafaxine is an antidepressant drug with demonstrated serotonin (5-HT) and
norepinephrine (NE) reuptake blockade properties in electrophysiological and microdialysis …

Norepinephrine transporter gene variants and remission from depression with venlafaxine treatment in older adults

VS Marshe, M Maciukiewicz, S Rej… - American Journal of …, 2017 - Am Psychiatric Assoc
Objective: The primary objective of this study was to investigate five putatively functional
variants of the norepinephrine transporter (SLC6A2, NET) and serotonin transporter …

Postpartum hemorrhage and use of serotonin reuptake inhibitor antidepressants in pregnancy

GE Hanley, K Smolina, B Mintzes… - Obstetrics & …, 2016 - journals.lww.com
OBJECTIVE: To examine whether using selective serotonin reuptake inhibitors and selective
serotonin–norepinephrine reuptake inhibitors in pregnancy is associated with an increased …

Adverse cardiac events in older patients receiving venlafaxine: a population-based study

JM Ho, T Gomes, SE Straus, PC Austin… - The Journal of clinical …, 2014 - psychiatrist.com
Objective: Venlafaxine is a commonly prescribed antidepressant, but whether its
noradrenergic effects impart increased cardiovascular risk is unknown. We sought to …

[HTML][HTML] Venlafaxine vs. fluoxetine in postmenopausal women with major depressive disorder: an 8-week, randomized, single-blind, active-controlled study

J Zhou, X Wang, L Feng, L Xiao, R Yang, X Zhu, H Shi… - BMC psychiatry, 2021 - Springer
Background In the population of postmenopausal patients with major depressive disorder
(MDD), the superiority of serotonin-norepinephrine reuptake inhibitors (SNRIs) over …

Effects of different doses of venlafaxine on serotonin and norepinephrine reuptake in healthy volunteers

P Blier, É Saint-André, C Hébert… - International Journal …, 2007 - academic.oup.com
Venlafaxine is generally considered to be a dual 5-HT and NE reuptake inhibitor when it is
used at doses above 75 mg/d in humans. While its 5-HT reuptake-inhibiting property has …

Naloxone displacement at opioid receptor sites measured in vivo in the human brain

JK Melichar, DJ Nutt, AL Malizia - European journal of pharmacology, 2003 - Elsevier
We report the use of a sensitive non-tomographic positron detecting system to measure the
dose–response curve of naloxone in human brain.[11C] Diprenorphine was administered to …