Signals of energy homeostasis interact closely with neural circuits of motivation to control
food intake. An emerging hypothesis is that the transition to maladaptive feeding behavior …

Orexins (hypocretins) are two peptides (orexin A and B) produced from the pre-pro-orexin
precursor and expressed in a limited region of dorsolateral hypothalamus. Orexins were …

Recently published work and emerging research efforts have suggested that the olfactory
system is intimately linked with the endocrine systems that regulate or modify energy …

The prevalence of obesity has markedly increased over the past few decades. Exploration of
how hunger and satiety signals influence the reward system can help us understand non …

The mesolimbic dopaminergic system (ML-DA) allows adapted interactions with the
environment and is therefore of critical significance for the individual's survival. The ML-DA …

The endocannabinoid system has emerged as a key player in the control of eating.
Endocannabinoids, including 2-arachidonoylglycerol (2-AG) and anandamide (AEA) …

In the present article, we provide a brief review of current knowledge regarding the effects
induced by physical exercise on hippocampus. Research involving animals and humans …

The basal forebrain (BF) cholinergic system has an important role in attentive functions. The
cholinergic system can be activated by different inputs, and in particular, by orexin neurons …

Highlights•Deficient orexin signaling results in chronic sleepiness and episodes of
cataplexy.•Orexin neurons fire most frequently during active wakefulness and high …

Growing evidence indicates that an increase of orexin (or hypocretin) signaling is involved in
the pathophysiology of major depression, but little is known regarding the causal link …