Basket trials in oncology: a systematic review of practices and methods, comparative analysis of innovative methods, and an appraisal of a missed opportunity
A Kasim, N Bean, SJ Hendriksen, TT Chen… - Frontiers in …, 2023 - frontiersin.org
Background Basket trials are increasingly used in oncology drug development for early
signal detection, accelerated tumor-agnostic approvals, and prioritization of promising tumor …
signal detection, accelerated tumor-agnostic approvals, and prioritization of promising tumor …
Basket Trials: Past, Present, and Future
YR Murciano-Goroff, M Uppal, M Chen… - Annual Review of …, 2023 - annualreviews.org
Large-scale tumor molecular profiling has revealed that diverse cancer histologies are
driven by common pathways with unifying biomarkers that can be exploited therapeutically …
driven by common pathways with unifying biomarkers that can be exploited therapeutically …
[HTML][HTML] The ESMO Tumour-Agnostic Classifier and Screener (ETAC-S): a tool for assessing tumour-agnostic potential of molecularly guided therapies and for steering …
CB Westphalen, D Martins-Branco, JR Beal… - Annals of …, 2024 - Elsevier
Background Advances in precision oncology led to approval of tumour-agnostic molecularly
guided treatment options (MGTOs). The minimum requirements for claiming tumour-agnostic …
guided treatment options (MGTOs). The minimum requirements for claiming tumour-agnostic …
Neoadjuvant therapy in non-small cell lung cancer: basis, promise, and challenges
Introduction Survival rates for early-stage non-small cell lung cancer (NSCLC) remain poor
despite the decade-long established standard of surgical resection and systemic adjuvant …
despite the decade-long established standard of surgical resection and systemic adjuvant …
[HTML][HTML] Liquid and Tissue Biopsies for Lung Cancer: Algorithms and Perspectives
P Hofman - Cancers, 2024 - mdpi.com
Simple Summary A liquid biopsy (LB) is now considered to be a valuable diagnostic tool for
advanced and metastatic nonsquamous nonsmall cell lung cancer (NS-NSCLC) patients …
advanced and metastatic nonsquamous nonsmall cell lung cancer (NS-NSCLC) patients …
Risk and benefit for basket trials in oncology: a systematic review and meta-analysis
Background Oncology research is increasingly adopting new clinical trial models that
implement the concept of precision medicine. One of these is the basket clinical trial design …
implement the concept of precision medicine. One of these is the basket clinical trial design …