Cancer Stem Cells Cancers arise in tissues that can replicate and self-renew. Like normal
tissues, cancers can replenish themselves, grow, and metastasize because of stem cells that …

BACKGROUND In adult mammalian organisms, multiple tissues—including the skin, blood,
stomach, and intestines—are entrapped in a state of permanent regeneration; older cells are …

Spatial transcriptomic technologies and spatially annotated single-cell RNA sequencing
datasets provide unprecedented opportunities to dissect cell–cell communication (CCC) …

The lung is an architecturally complex organ comprising a heterogeneous mixture of various
epithelial and mesenchymal lineages. We use single-cell RNA sequencing and signaling …

INTRODUCTION Tissue stem cells respond to and integrate environmental cues to
determine their fate and function. Injury induces radical changes in the microenvironment …

For unknow reasons, the melanocyte stem cell (McSC) system fails earlier than other adult
stem cell populations, which leads to hair greying in most humans and mice,. Current dogma …

Mammalian wounds typically heal by fibrotic repair without hair follicle (HF) regeneration.
Fibrosis and regeneration are currently considered the opposite end of wound healing. This …

The skin protects mammals from insults, infection and dehydration and enables
thermoregulation and sensory perception. Various skin-resident cells carry out these diverse …

Chronic, sustained exposure to stressors can profoundly affect tissue homeostasis, although
the mechanisms by which these changes occur are largely unknown. Here we report that the …

Wound represents a significant socioeconomic burden for both affected individuals and as a
whole healthcare system. Accordingly, stem cells have garnered attention due to their …