Deep brain stimulation (DBS) is an established procedure for the symptomatic treatment of
Parkinson's disease. Several deep brain nuclei have been stimulated, producing a wide …

Pedunculopontine nucleus region deep brain stimulation (DBS) is a promising but
experimental therapy for axial motor deficits in Parkinson's disease (PD), particularly gait …

The demonstration that dopamine loss is the key pathological feature of Parkinson's disease
(PD), and the subsequent introduction of levodopa have revolutionalized the field of PD …

The benefit of deep brain stimulation (DBS) in controlling the motor symptoms of Parkinson's
disease is well established, however, the impact on the non-motor symptoms (NMS) remains …

Mesial temporal lobe epilepsy (mTLE) is a neurological disorder in which patients suffer
from frequent consciousness‐impairing seizures, broad neurocognitive deficits, and …

In patients with Parkinson's disease, gait and balance difficulties have emerged as some of
the main therapeutic concerns. During earlier stages of the disease, the dopamine …

Background STN-DBS is well established to improve motor symptoms and quality of life in
patients with PD. While non-motor symptoms are crucial for quality of life in these patients …

We present data from animal studies showing that the pedunculopontine tegmental nucleus—
conserved through evolution, compartmentalized, and with a complex pattern of inputs and …

Background High frequency stimulation (HFS) of the subthalamic nucleus (STN-DBS) has
been shown to have little impact on postural control and gait improvements in Parkinson's …

Sleep disorders are integral to Parkinson's disease (PD). Insomnia, an inability to maintain
stable sleep, affects most patients and is widely rated as one of the most debilitating facets of …