Pulmonary hypertension (PH) is a serious disease characterized by various degrees of
pulmonary vasoconstriction and progressive fibroproliferative remodeling and inflammation …

Background Pulmonary hypertension (PH) is a devastating disease with poor prognosis and
high mortality. Hypoxia induced pulmonary hypertension (HPH) is a persistent threat to …

Introduction Piezo1 is an important mechanosensitive channel implicated in vascular
remodeling. However, the role of Piezo1 in different types of vascular cells during the …

Enhanced vasoconstriction and decreased vasodilatation due to endothelial dysfunction
contribute to the progression of hypertension. Angiotensin (Ang)-(1-7) plays important roles …

Pulmonary hypertension (PH) is a cardiopulmonary disease characterized by a progressive
increase in pulmonary vascular resistance. One of the initial pathogenic factors of PH is …

Disordered proliferation and angiogenesis of pulmonary artery endothelial cells is an
important stage in the development of pulmonary arterial hypertension. Recent studies …

Pulmonary hypertension (PH) is characterized by pulmonary vascular remodeling,
respiratory muscle and cardiac impairments, and exercise intolerance. Specifically, impaired …

Pulmonary hypertension (PH) is a devastating disease characterized by vascular
remodeling, resulting in right ventricular failure and death. Dysregulation of energy …

The Sugen 5416/hypoxia (Su/Hx) rat model of pulmonary arterial hypertension (PAH)
demonstrates most of the distinguishing features of PAH in humans, including increased …

Pulmonary hypertension (PH) is associated with meta-inflammation related to obesity but the
role of adipose tissue in PH pathogenesis is unknown. We hypothesized that adipose tissue …