4D flow MRI hemodynamic biomarkers for cerebrovascular diseases

A Wåhlin, A Eklund, J Malm - Journal of Internal Medicine, 2022 - Wiley Online Library
Alterations in cerebral blood flow are common in several neurological diseases among the
elderly including stroke, cerebral small vessel disease, vascular dementia, and Alzheimer's …

4D flow MRI for non-invasive measurement of blood flow in the brain: a systematic review

AG Morgan, MJ Thrippleton… - Journal of Cerebral …, 2021 - journals.sagepub.com
The brain's vasculature is essential for brain health and its dysfunction contributes to the
onset and development of many dementias and neurological disorders. While numerous in …

Normative cerebral hemodynamics in middle-aged and older adults using 4D flow MRI: initial analysis of vascular aging

GS Roberts, A Peret, EM Jonaitis, RL Koscik… - Radiology, 2023 - pubs.rsna.org
Background Characterizing cerebrovascular hemodynamics in older adults is important for
identifying disease and understanding normal neurovascular aging. Four-dimensional (4D) …

In vivo pulsatility measurement of cerebral microcirculation in rodents using dynamic ultrasound localization microscopy

C Bourquin, J Poree, F Lesage… - IEEE Transactions on …, 2021 - ieeexplore.ieee.org
An increased pulse pressure, due to arteries stiffening with age and cardiovascular disease,
may lead to downstream brain damage in microvessels and cognitive decline. Brain-wide …

Cerebral arterial pulsatility is linked to hippocampal microvascular function and episodic memory in healthy older adults

T Vikner, A Eklund, N Karalija, J Malm… - Journal of Cerebral …, 2021 - journals.sagepub.com
Microvascular damage in the hippocampus is emerging as a central cause of cognitive
decline and dementia in aging. This could be a consequence of age-related decreases in …

[HTML][HTML] Higher intracranial arterial pulsatility is associated with presumed imaging markers of the glymphatic system: An explorative study

L Xie, Y Zhang, H Hong, S Xu, L Cui, S Wang, J Li… - Neuroimage, 2024 - Elsevier
Background Arterial pulsation has been suggested as a key driver of paravascular
cerebrospinal fluid flow, which is the foundation of glymphatic clearance. However, whether …

Maternal but not fetoplacental health can be improved by metformin in a murine diet‐induced model of maternal obesity and glucose intolerance

A Hufnagel, DS Fernandez‐Twinn… - The Journal of …, 2022 - Wiley Online Library
Maternal obesity is a global problem that increases the risk of short‐and long‐term adverse
outcomes for mother and child, many of which are linked to gestational diabetes mellitus …

Non‐invasive assessment of damping of blood flow velocity Pulsatility in cerebral arteries with MRI

T Arts, LP Onkenhout, RP Amier… - Journal of Magnetic …, 2022 - Wiley Online Library
Background Damping of heartbeat‐induced pressure pulsations occurs in large arteries
such as the aorta and extends to the small arteries and microcirculation. Since recently, 7 T …

Diagnostic separation of conventional⩾ 50% carotid stenosis and near-occlusion with phase-contrast MRI

M Holmgren, A Henze, A Wåhlin… - European Stroke …, 2024 - journals.sagepub.com
Introduction: The aim of this study was to assess sensitivity, specificity and interrater
reliability of phase-contrast MRI (PC-MRI) for diagnosing carotid near-occlusion. Patients …

From 2D to 4D phase‐contrast MRI in the neurovascular system: will it be a quantum jump or a fancy decoration?

SW Youn, J Lee - Journal of Magnetic Resonance Imaging, 2022 - Wiley Online Library
Considering the crosstalk between the flow and vessel wall, hemodynamic assessment of
the neurovascular system may offer a well‐integrated solution for both diagnosis and …