Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors
S Rendic, FJD Carlo - Drug metabolism reviews, 1997 - Taylor & Francis
Human Cytochrome P450 Enzymes: A Status Report Summarizing Their Reactions, Substrates,
Inducers, and Inhibitors Page 1 DRUG METABOLISM REVIEWS, 29( 1&2), 413-580 (1997) …
Inducers, and Inhibitors Page 1 DRUG METABOLISM REVIEWS, 29( 1&2), 413-580 (1997) …
Clinical significance of the cytochrome P450 2C19 genetic polymorphism
Abstract Cytochrome P450 2C19 (CYP2C19) is the main (or partial) cause for large
differences in the pharmacokinetics of a number of clinically important drugs. On the basis of …
differences in the pharmacokinetics of a number of clinically important drugs. On the basis of …
Inhibition and induction of cytochrome P450 and the clinical implications
JH Lin, AYH Lu - Clinical pharmacokinetics, 1998 - Springer
The cytochrome P450s (CYPs) constitute a superfamily of isoforms that play an important
role in the oxidative metabolism of drugs. Each CYP isoform possesses a characteristic …
role in the oxidative metabolism of drugs. Each CYP isoform possesses a characteristic …
Summary of information on human CYP enzymes: human P450 metabolism data
S Rendic - Drug metabolism reviews, 2002 - Taylor & Francis
This chapter is an update of the data on substrates, reactions, inducers, and inhibitors of
human CYP enzymes published previously by Rendic and DiCarlo Citation 1a, Citation 1b …
human CYP enzymes published previously by Rendic and DiCarlo Citation 1a, Citation 1b …
Use of In Vitro and In Vivo Data to Estimate the Likelihood of Metabolic Pharmacokinetic Interactions
RJ Bertz, GR Granneman - Clinical pharmacokinetics, 1997 - Springer
This article reviews the information available to assist pharmacokineticists in the prediction
of metabolic drug interactions. Significant advances in this area have been made in the last …
of metabolic drug interactions. Significant advances in this area have been made in the last …
Molecular basis of ethnic differences in drug disposition and response
HG Xie, RB Kim, AJJ Wood… - Annual review of …, 2001 - annualreviews.org
Ethnicity is an important demographic variable contributing to interindividual variability in
drug metabolism and response. In this rapidly expanding research area many genetic …
drug metabolism and response. In this rapidly expanding research area many genetic …
Mechanisms of clinically relevant drug interactions associated with tacrolimus
U Christians, W Jacobsen, LZ Benet… - Clinical pharmacokinetics, 2002 - Springer
The clinical management of tacrolimus, a macrolide used as immunosuppressant after
transplantation, is complicated by its narrow therapeutic index in combination with inter-and …
transplantation, is complicated by its narrow therapeutic index in combination with inter-and …
CYP2C9 Genotype‐guided Warfarin Prescribing Enhances the Efficacy and Safety of Anticoagulation: A Prospective Randomized Controlled Study
Warfarin anticoagulation effect is characterized by marked variability, some of which has
been attributed to CYP2C9 polymorphisms. This study prospectively examines whether a …
been attributed to CYP2C9 polymorphisms. This study prospectively examines whether a …
Drug-drug interaction profiles of proton pump inhibitors
R Ogawa, H Echizen - Clinical pharmacokinetics, 2010 - Springer
Proton pump inhibitors (PPIs) are widely prescribed for the treatment of gastric acid-related
disorders and the eradication of Helicobacter pylori. In addition, they are routinely …
disorders and the eradication of Helicobacter pylori. In addition, they are routinely …
Pharmacogenetics of long-term responses to antiretroviral regimens containing Efavirenz and/or Nelfinavir: an Adult Aids Clinical Trials Group Study
DW Haas, LM Smeaton, RW Shafer… - The Journal of …, 2005 - academic.oup.com
Background Efavirenz and nelfinavir are metabolized by cytochrome P-450 (CYP) 2B6 and
CYP2C19, respectively, with some involvement by CYP3A. Nelfinavir is a substrate for P …
CYP2C19, respectively, with some involvement by CYP3A. Nelfinavir is a substrate for P …