The present review paper focuses on the chemistry of oxidative stress mitigation by
antioxidants. Oxidative stress is understood as a lack of balance between the pro-oxidant …

Oxidative stress is increasingly recognized as a central event contributing to the
degeneration of dopaminergic neurons in the pathogenesis of Parkinson's disease (PD) …

Neuroinflammation and mitochondrial dysfunction are common features of chronic
neurodegenerative diseases of the central nervous system. Both conditions can lead to …

Currently, the only widely available metabolic imaging technique in the clinic is positron
emission tomography (PET) detection of the radioactive glucose analog 2-18F-fluoro-2 …

Leukodystrophies comprise a large group of rare genetic disorders primarily affecting CNS
white matter. Historically, the diagnostic process was slow and patient prognosis regarded …

The last century has seen an increase in our life expectancy. As a result, various age-related
diseases, such as neurodegenerative diseases (NDs), have emerged, representing new …

Leigh syndrome, also referred to as subacute necrotizing encephalomyelopathy, is a severe,
early-onset neurodegenerative disorder that is relentlessly progressive and devastating to …

Neuroinflammatory and neurodegenerative diseases are a major public health problem
worldwide, especially with the increase of life-expectancy observed during the last decades …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that produces a
selective loss of the motor neurons of the spinal cord, brain stem and motor cortex. Oxidative …

Remyelination is a major therapeutic goal in human myelin disorders, serving to restore
function to demyelinated axons and providing neuroprotection. The target disorders that …