Strengths, weaknesses, opportunities and challenges for long acting injectable therapies: Insights for applications in HIV therapy

A Owen, S Rannard - Advanced drug delivery reviews, 2016 - Elsevier
Advances in solid drug nanoparticle technologies have resulted in a number of long-acting
(LA) formulations with the potential for once monthly or longer administration. Such …

Fluorescent organic nanocrystals and non-doped nanoparticles for biological applications

S Fery-Forgues - Nanoscale, 2013 - pubs.rsc.org
The recently developed fluorescent organic nanocrystals and non-doped nanoparticles
(FONs) occupy a special position among other nanoparticle systems that are used for …

Impacts of particle shapes on the oral delivery of drug nanocrystals: Mucus permeation, transepithelial transport and bioavailability

M Guo, M Wei, W Li, M Guo, C Guo, M Ma… - Journal of controlled …, 2019 - Elsevier
For drug nanocrystals (NCs), particle shapes can affect aqueous solubility, dissolution rate
and oral bioavailability. However, the effects of particle shapes on the transport of NCs …

Long-acting injectable atovaquone nanomedicines for malaria prophylaxis

RP Bakshi, LM Tatham, AC Savage, AK Tripathi… - Nature …, 2018 - nature.com
Chemoprophylaxis is currently the best available prevention from malaria, but its efficacy is
compromised by non-adherence to medication. Here we develop a long-acting injectable …

Photoresponsive polymer nanocarriers with multifunctional cargo

S Swaminathan, J Garcia-Amorós, A Fraix… - Chemical Society …, 2014 - pubs.rsc.org
Nanoparticles with photoresponsive character can be assembled from amphiphilic
macromolecular components and hydrophobic chromophores. In aqueous solutions, the …

Small-sized mPEG–PLGA nanoparticles of Schisantherin A with sustained release for enhanced brain uptake and anti-parkinsonian activity

T Chen, C Li, Y Li, X Yi, R Wang… - ACS applied materials …, 2017 - ACS Publications
Schisantherin A (SA) is a promising anti-Parkinsonism natural product. However, its poor
water solubility and rapid serum clearance impose significant barriers to delivery of SA to the …

Antiretroviral solid drug nanoparticles with enhanced oral bioavailability: production, characterization, and in vitro–in vivo correlation

TO McDonald, M Giardiello, P Martin… - Advanced …, 2014 - Wiley Online Library
Nanomedicine strategies have produced many commercial products. However, no orally
dosed HIV nanomedicines are available clinically to patients. Although nanosuspensions of …

Multifunctional nanoparticles enable efficient oral delivery of biomacromolecules via improving payload stability and regulating the transcytosis pathway

Y Zheng, J Wu, W Shan, L Wu, R Zhou… - … applied materials & …, 2018 - ACS Publications
In oral delivery of biomacromolecules, ligand-modified nanoparticles (NPs) have emerged
as a promising tool to improve the epithelial uptake of the loaded protein/peptide …

Aggregates of quadrupolar dyes for two-photon absorption: the role of intermolecular interactions

S Sanyal, A Painelli, SK Pati, F Terenziani… - Physical Chemistry …, 2016 - pubs.rsc.org
We present a theoretical investigation of small aggregates of quadrupolar (A–π–D–π–A or D–
π–A–π–D) charge-transfer dyes, with attention focused on the role of intermolecular …

Molecular Self‐Doping Controls Luminescence of Pure Organic Single Crystals

OD Parashchuk, AA Mannanov… - Advanced Functional …, 2018 - Wiley Online Library
Organic optoelectronics calls for materials combining bright luminescence and efficient
charge transport. The former is readily achieved in isolated molecules, while the latter …