Formation of the 3′ end of a eukaryotic mRNA is a key step in the production of a mature
transcript. This process is mediated by a number of protein factors that cleave the pre …

Most human genes have multiple sites at which RNA 3ʹ end cleavage and polyadenylation
can occur, enabling the expression of distinct transcript isoforms under different conditions …

Recent advances in neoantigen research have accelerated the development and regulatory
approval of tumor immunotherapies, including cancer vaccines, adoptive cell therapy and …

Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic
target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations …

Background: Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX)
Syndrome is a rare recessive disorder caused by mutations in the FOXP3 gene. In addition …

A large number of mutations in genes that encode RNA binding proteins cause human
disease. Many of these RNA binding proteins mediate key steps in post-transcriptional …

Nearly all eukaryotic messenger RNA precursors must undergo cleavage and
polyadenylation at their 3′-end for maturation. A crucial step in this process is the …

Meiotic resumption‐coupled degradation of maternal transcripts occurs during oocyte
maturation in the absence of mRNA transcription. The CCR 4–NOT complex has been …

Abstract 3′ end processing of most human mRNAs is carried out by the cleavage and
polyadenylation specificity factor (CPSF; CPF in yeast). Endonucleolytic cleavage of the …

Adenosine deaminases acting on RNA (ADARs) are the primary factors underlying
adenosine to inosine (A-to-I) editing in metazoans. Here we report the first global study of …