RNA dependent RNA polymerase (RdRp) is one of the most versatile enzymes of RNA
viruses that is indispensable for replicating the genome as well as for carrying out …

Eukaryotes and bacteria can be infected with a wide variety of RNA viruses. On average,
these pathogens share little sequence similarity and use different replication and …

Birnaviridae is a family of viruses with bi-segmented dsRNA genomes totalling about 6 kbp
forming icosahedral, non-enveloped virions. The family includes four genera, members of …

Infectious bursal disease virus (IBDV) causes an economically significant disease of
chickens worldwide. Very virulent IBDV (vvIBDV) strains have emerged and induce as much …

With the arrival of the Covid-19 pandemic, anti-viral agents have regained center stage in
the arena of medicine. Out of the various drug targets involved in managing RNA-viral …

Arenaviruses form a noncytolytic infection in their rodent hosts, yet can elicit severe
hemorrhagic disease in humans. How arenaviruses regulate gene expression remains …

RNA viruses typically encode their own RNA-dependent RNA polymerase (RdRP) to ensure
genome replication within the infected cells. RdRP function is critical not only for the virus life …

Infectious bursal disease virus (IBDV) is a double-stranded RNA (dsRNA) virus belonging to
the genus Avibirnavirus in the family Birnaviridae. It can cause serious failure of vaccination …

Viral RNA dependent polymerases (vRdPs) are present in all RNA viruses; unfortunately,
their sequence similarity is too low for phylogenetic studies. Nevertheless, vRdP protein …

RNA viruses are the fastest evolving known biological entities. Consequently, the sequence
similarity between homologous viral proteins disappears quickly, limiting the usability of …