Despite declines in heart failure morbidity and mortality with current therapies,
rehospitalization rates remain distressingly high, substantially affecting individuals, society …

Since the discovery that mitochondrial membrane permeabilization represents a critical step
in the regulation of intrinsic apoptosis, mitochondria have been viewed as pluripotent …

Identifying a bona fide population of cardiac stem cells (CSCs) is a critical step for
developing cell-based therapies for heart failure patients. Previously, cardiac c-kit+ cells …

MicroRNAs (miRNAs) are genomically encoded small RNAs used by organisms to regulate
the expression of proteins generated from messenger RNA transcripts. The in vivo …

The paracrine theory has recently changed the view of the biological action of stem cells and
of the subsequent potential application of stem cells in regenerative medicine. Indeed, most …

A defining cellular event in the transition from compensated hypertrophy to dilated
cardiomyopathy is cardiomyocyte drop-out due to apoptosis, programmed necrosis, and …

In this study, we report on recent advances on the functions of embryonic, fetal, and adult
stem cell progenitors for tissue regeneration and cancer therapies. We describe new …

Met tyrosine kinase receptor, also known as c-Met, is the HGF (hepatocyte growth factor)
receptor. The HGF/Met pathway has a prominent role in cardiovascular remodelling after …

Cardiovascular diseases (CVDs) are still a major cause of people deaths worldwide, and
mesenchymal stem cells (MSCs) transplantation holds great promise due to its capacity to …

Heart diseases, including myocardial infarction (MI) and congestive heart failure (CHF),
have high mortality rates. Both MI and CHF are characterized by cardiac muscle damage …