The past few decades are characterized by an explosive evolution of genetics and
molecular cell biology. Advances in chemistry and engineering have enabled increased …

Acute kidney injury (AKI) is a common problem in both the inpatient and outpatient setting
and often results from drug toxicities. Traditional methods of identifying AKI, through …

Renal cell carcinoma (RCC) is a heterogeneous cancer often showing late symptoms. Until
now, some candidate protein markers have been proposed for its diagnosis. Metabolomics …

Liver transplant recipients are at increasingly high risk for suffering from impaired renal
function and probable need of renal replacement therapy. Extended criteria organs and …

Abstract Currently,> 50% of candidates for solid organ transplantation in Europe and the US
are aged> 50 years while approximately 15% of potential recipients are aged≥ 65 years …

Epithelial-mesenchymal transition (EMT), a process which describes the trans-differentiation
of epithelial cells into motile mesenchymal cells, is pivotal in stem cell behavior …

Introduction Systemic lupus erythematosus (SLE or lupus) is a chronic autoimmune disease,
and kidney involvement with SLE, aka lupus nephritis (LN), is a frequent and severe …

Mycophenolic acid (MPA) is used as an immunosuppressant after organ transplantation and
for the treatment of immune diseases. There is increasing evidence that therapeutic drug …

WHAT IS ALREADY KNOWN ABOUT THE SUBJECT• Ciclosporin's nephrotoxicity initially
targets the proximal tubule and is, at least in part, driven by increased formation of oxygen …

Metabolomics is a new approach based on the systematic study of the full complement of
metabolites in a biological sample. This technology consists of two sequential steps:(1) an …