Diabetes is a chronic metabolic disease that is increasing in prevalence and causes many
complications. Diabetic cardiomyopathy (DCM) is a complication of diabetes that is …

Underlying type 1 diabetes is a genetic aetiology dominated by the influence of specific HLA
haplotypes involving primarily the class II DR-DQ region. In genetically predisposed children …

The gastrointestinal microbiome is a complex ecosystem with functions that shape human
health. Studying the relationship between taxonomic alterations and functional …

Phytochemicals are known to have anti-inflammatory effects in vitro and in vivo, such as in
inflammatory disease model systems. Inflammation is an essential immune response to …

Hyperglycemia activates toll-like receptor 4 (TLR4) to induce inflammation in diabetic
cardiomyopathy (DCM). However, the mechanisms of TLR4 activation remain unclear. Here …

Abstract Chitinase 3-like 1 (CHI3L1) is a secreted glycoprotein that mediates inflammation,
macrophage polarization, apoptosis, and carcinogenesis. The expression of CHI3L1 is …

Berberine (BBR) is a promising anti-diabetic isoquinoline alkaloid from Rhizoma coptidis,
while its bioavailability was extremely low. Here, the existing form and pharmacokinetics of …

Rosacea is a common chronic inflammatory disease affecting the facial skin whose etiology
and pathophysiology are the subject of much investigation. Risk factors include genetic and …

Diabetes mellitus is considered to be a global epidemic. The combination of genetic
susceptibility and an unhealthy lifestyle is considered to be the main trigger of this metabolic …

For decades, research in autoimmunity has focused primarily on immune contributions to
disease. Yet recent studies report elevated levels of reactive oxygen species and abnormal …