Patterns of replication within eukaryotic genomes correlate with gene expression, chromatin
structure, and genome evolution. Recent advances in genome-scale mapping of replication …

A molecular motor is made of either a single macromolecule or a macromolecular complex.
Just like their macroscopic counterparts, molecular motors “transduce” input energy into …

Background DNA replication in mammalian cells occurs in a defined temporal order during
S phase, known as the replication timing (RT) programme. Replication timing is …

Little is known about replication fork velocity variations along eukaryotic genomes, since
reference techniques to determine fork speed either provide no sequence information or …

DNA replication enables genetic inheritance across the kingdoms of life. Replication occurs
with a defined temporal order known as the replication timing (RT) programme, leading to …

Many fundamental aspects of DNA replication, such as the exact locations where DNA
synthesis is initiated and terminated, how frequently origins are used, and how fork …

Abstract OriDB (http://www. oridb. org/) is a database containing collated genome-wide
mapping studies of confirmed and predicted replication origin sites. The original database …

The ability of a eukaryotic cell to precisely and accurately replicate its DNA is crucial to
maintain genome stability. Here we describe our current understanding of the process by …

Genome-wide replication timing studies have suggested that mammalian chromosomes
consist of megabase-scale domains of coordinated origin firing separated by large …

Replication of mammalian genomes starts at sites termed replication origins, which
historically have been difficult to locate as a result of large genome sizes, limited power of …