The current enthusiasm for pharmacogenetics draws much of its inspiration from the
relatively few examples of polymorphisms that have marked and seemingly clinically …

We describe a new computational method for estimating the probability that a point mutation
at each position in a genome will influence fitness. These'fitness consequence'(fitCons) …

We sequenced 122 miRNAs in 10 primate species to reveal conservation characteristics of
miRNA genes. Strong conservation is observed in stems of miRNA hairpins and increased …

Multiple-sequence alignment analysis is a powerful approach for understanding
phylogenetic relationships, annotating genes, and detecting functional regulatory elements …

Age-related cataract is a major cause of blindness worldwide, and cortical cataract is the
second most prevalent type of age-related cataract. Although a significant fraction of age …

Association of alternative splicing (AS) with accelerated rates of exon evolution in some
organisms has recently aroused widespread interest in its role in evolution of eukaryotic …

The LEM (lamina-associated polypeptide–emerin–MAN1) domain is a motif shared by a
group of lamin-interacting proteins in the inner nuclear membrane (INM) and in the …

IL-13 is a central mediator of allergic inflammation. The single nucleotide polymorphism IL13-
1112C> T (rs1800925) is associated with allergic phenotypes in ethnically distinct …

All viruses produce infectious particles that possess some degree of stability in the
extracellular environment yet disassemble upon cell contact and entry. For the …

Hereditary nonpolyposis colorectal cancer (HNPCC) is associated with defects in DNA
mismatch repair. Mutations in either hMSH2 or hMLH1 underlie the majority of HNPCC …