During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …

The mesocorticolimbic pathway is canonically known as the" reward pathway." Embedded
within the center of this circuit is the striatum, a massive and complex network hub that …

Abstract µ-Opioid peptide receptor (MOPR) stimulation alters respiration, analgesia and
reward behaviour, and can induce substance abuse and overdose,–. Despite its evident …

Dopamine neurons of the ventral tegmental area (VTA DA) respond to food and social
stimuli and contribute to both forms of motivation. However, it is unclear whether the same or …

Unravelling the pathophysiology of depression is a unique challenge. Not only are
depressive syndromes heterogeneous and their aetiologies diverse, but symptoms such as …

Depression is one of the most prevalent forms of mental disorders and is the most common
cause of disability in the Western world. Besides, the harmful effects of stress-related mood …

Chronic energy deficiency can impair the hypothalamic-pituitary-gonadal (HPG) axis and
lead to hypothalamic anovulation in underweight women. This review presents the …

Obesity is a global epidemic that contributes to a number of health complications including
cardiovascular disease, type 2 diabetes, cancer and neuropsychiatric disorders …

The hypothalamus is among the most phylogenetically conserved regions in the vertebrate
brain, reflecting its critical role in maintaining physiological and behavioural homeostasis. By …

The hedonic properties of food can stimulate feeding behaviour even when energy
requirements have been met, contributing to weight gain and obesity. Similarly, the hedonic …