Introduction: The opioid epidemic has become an immense problem in North America, and
despite decades of research on the most effective means to treat opioid use disorder (OUD) …

Recent studies have shown that the endocannabinoid system is involved in the common
neurobiological mechanism underlying drug addiction. This system participates in the …

Although anecdotal reports suggest that cannabis may be used to alleviate symptoms of
depression, the psychotropic effects and abuse liability of this drug prevent its therapeutic …

▪ Abstract CB1 and CB2 cannabinoid receptors are the primary targets of endogenous
cannabinoids (endocannabinoids). These G protein–coupled receptors play an important …

The identification of the molecular mechanisms involved in nicotine addiction and its
cognitive consequences is a worldwide priority for public health. Novel in vivo paradigms …

Cannabis use is a hypothesized gateway to subsequent abuse of other drugs such as
heroin. We currently assessed whether Δ-9-tetrahydrocannabinol (THC) exposure during …

Food, drugs and brain stimulation can serve as strong rewarding stimuli and are all believed
to activate common brain circuits that evolved in mammals to favour fitness and survival. For …

Ethanol and opiate self-administration are sensitive to manipulations of cannabinoid CB1
receptor function and, from this, a role for the endogenous cannabinoid system in the …

Two are the issues on cannabis addiction that provoke more controversy from a research
perspective. The first one is related to the development of tolerance phenomena and, in …

This review examines the development of cannabinoid CB1 receptor antagonists as a new
class of therapeutic agents for drug addiction. Abused drugs [alcohol, opiates, Δ9 …