Ankylosing spondylitis (AS) is a potentially disabling form of seronegative spondyloarthritis.
The main symptom of AS is inflammatory spinal pain; with time, some patients develop …

The strong association between HLA-B27 and ankylosing spondylitis has been known for
more than 33 years, but the enigma of the pathogenetic role of the gene and its product has …

Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million
people worldwide, with increasing incidence in westernized countries,. To elucidate the …

HLA-B27 (Human Leukocyte Antigen-B27) accounts approximately for the one third of the
overall genetic susceptibility to spondylorthropathies (SpAs). Up to 70 HLA-B27 subtypes …

The association of HLA-B27 with ankylosing spondylitis, a chronic inflammatory disease of
the axial skeleton, and other spondyloarthropathies, is among the strongest of an MHC …

Major histocompatibility complex (MHC) class I proteins are expressed on the cell surface
where they present foreign and self-peptides to effector cells of the immune system. While …

This article summarizes the proceedings of a one-day international workshop held in July
2009 on the role of HLA-B27 in the pathogenesis of ankylosing spondylitis (AS) and related …

The immune system is constantly challenged, being required to protect the organism against
a wide variety of infectious pathogens and, at the same time, to avoid autoimmune disorders …

Reactive arthritis (ReA) is an HLA-B27-associated spondyloarthropathy that is triggered by
diverse bacteria, including Chlamydia trachomatis, a frequent intracellular parasite. HLA …

A structural characterization of the interaction between αβ TCRs and cognate peptide–MHC
(pMHC) is central to understanding adaptive T cell–mediated immunity. X-ray …