Background The dietary consumption of cuprizone–a copper chelator–has long been known
to induce demyelination of specific brain structures and is widely used as model of multiple …

In human demyelinating diseases such as multiple sclerosis (MS), an imbalance between
demyelination and remyelination can trigger progressive degenerative processes. The …

Multiple Sclerosis (MS) is an immune-mediated neurological disorder, characterized by
central nervous system (CNS) inflammation, oligodendrocyte loss, demyelination, and …

Multiple sclerosis (MS) is a chronic inflammatory, demyelinating, and neurodegenerative
disease of the central nervous system (CNS). In people with MS, impaired remyelination and …

Multiple Sclerosis (MS) is traditionally considered an autoimmune-mediated demyelinating
disease, the pathoetiology of which is unknown. However, the key question remains whether …

The loss of myelinating oligodendrocytes is a key characteristic of many neurological
diseases, including Multiple Sclerosis (MS). In progressive MS, where effective treatment …

Multiple Sclerosis (MS) is a demyelinating disease of the human central nervous system
having an unconfirmed pathoetiology. Although animal models are used to mimic the …

Feeding cuprizone (CPZ) to mice causes demyelination and reactive gliosis in the central
nervous system (CNS), hallmarks of some neurodegenerative diseases like multiple …

Cuprizone (CPZ)-feeding in mice induces atrophy of peripheral immune organs (thymus and
spleen) and suppresses T-cell levels, thereby limiting its use as a model for studying the …

The demyelinating diseases of the central nervous system involve myelin abnormalities,
oligodendrocyte damage, and consequent glia activation. Neurotoxicant cuprizone (CPZ) …