Endogenous cytoplasmic DNA (cytoDNA) species are emerging as key mediators of
inflammation in diverse physiological and pathological contexts. Although the role of …

Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Constitutive heterochromatin is responsible for genome repression of DNA enriched in
repetitive sequences, telomeres, and centromeres. During physiological and pathological …

At the nuclear periphery, associations of chromatin with the nuclear lamina through lamina-
associated domains (LADs) aid functional organization of the genome. We review the …

Ageing is a complex biological process in which a gradual decline in physiological fitness
increases susceptibility to diseases such as neurodegenerative disorders and cancer …

Aging is a chronic yet natural physiological decline of the body. Throughout life, humans are
continuously exposed to a variety of exogenous and endogenous stresses, which engender …

Aging is the result of the accumulation of a wide variety of molecular and cellular damage
over time. This has been associated with a number of features termed hallmarks of aging …

SIRT7, a sirtuin family member implicated in aging and disease, is a regulator of metabolism
and stress responses. It remains elusive how human somatic stem cell populations might be …

Abstract Cyclic GMP–AMP synthase (cGAS), initially identified as a cytosolic DNA sensor,
detects DNA fragments to trigger an innate immune response. Recently, accumulating …

Celastrol, a pentacyclic tritepene extracted from Tripterygium Wilfordi plant, showing potent
liver protection effects on several liver‐related diseases. However, the anti‐inflammatory …